Human USP7 Recombinant Protein (N-His) (HV097022)

Name: Human USP7 Recombinant Protein (N-His)
Brand: abinScience
SKU: HV097022
Price: 211 USD
Availability: InStock

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Número de catálogo	HV097022
Descripción	Recombinant Human USP7 Protein, N-His (HV097022) expressed in E. coli, spanning Glu560-Asn1102. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Sistema de expresión	E. coli
Número de acceso	Q93009
Longitud de proteína	Glu560-Asn1102
Aplicaciones	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Especies	Homo sapiens (Human)
Naturaleza	Recombinant
Nivel de endotoxinas	Please contact with the lab for this information.
Pureza	>90% as determined by SDS-PAGE.
Peso molecular predicho	65.90 kDa
Forma	Lyophilized
Buffer de almacenamiento	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Reconstitución	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Envío	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Estabilidad y almacenamiento	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Nombres alternativos	Deubiquitinating enzyme 7, EC:3.4.19.12, HAUSP, Herpesvirus-associated ubiquitin-specific protease, USP7, Ubiquitin carboxyl-terminal hydrolase 7, Ubiquitin thioesterase 7, Ubiquitin-specific-processing protease 7
Fondo	Ubiquitin carboxyl-terminal hydrolase 7 is a ~128 kDa protein. Hydrolase that deubiquitinates target proteins such as ARMC5, FOXO4, DEPTOR, KAT5, p53/TP53, MDM2, ERCC6, DNMT1, UHRF1, PTEN, KMT2E/MLL5 and DAXX. Together with DAXX, prevents MDM2 self-ubiquitination and enhances the E3 ligase activity of MDM2 towards p53/TP53, thereby promoting p53/TP53 ubiquitination and proteasomal degradation. Deubiquitinates p53/TP53, preventing degradation of p53/TP53, and enhances p53/TP53-dependent transcription regulation, cell growth repression and apoptosis. Deubiquitinates p53/TP53 and MDM2 and strongly stabilizes p53/TP53 even in the presence of excess MDM2, and also induces p53/TP53-dependent cell growth repression and apoptosis. Deubiquitination of FOXO4 in presence of hydrogen peroxide is not dependent on p53/TP53 and inhibits FOXO4-induced transcriptional activity. 1. Li, M. et al. (2002) Nature 416, 648-53. PMID: 11923872 2. Li, M. et al. (2004) Molecular cell 13, 879-86. PMID: 15053880 3. van der Horst, A. et al. (2006) Nature cell biology 8, 1064-73. PMID: 16964248 4. Song, MS. et al. (2008) Nature 455, 813-7. PMID: 18716620 5. Zhang, J. et al. (2014) Nature communications 5, 5059. PMID: 25283148 6. Cui, H. et al. (2015) Nature communications 6, 6752. PMID: 25865756 7. Ding, X. et al. (2015) PloS one 10, e0145023. PMID: 26678539 8. Jiang, L. et al. (2017) The Journal of biological chemistry 292, 13296-13311. PMID: 28655758 9. Yan, G. et al. (2021) Journal of cellular and molecular medicine 25, 3149-3159. PMID: 33544460 10. Vega, M. et al. (2022) The Journal of biological chemistry 298, 101750. PMID: 35216969
Nota	For research use only

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Datasheet

Human USP7 Recombinant Protein (N-His).pdf

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