Human WDR81 Recombinant Protein (N-His) (HD280012)

Name: Human WDR81 Recombinant Protein (N-His)
Brand: abinScience
SKU: HD280012
Price: 211 USD
Availability: InStock

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Numéro de catalogue	HD280012
Description	Recombinant Human WDR81 Protein, N-His (HD280012) expressed in E. coli, spanning Gly337-Gln614. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Système d'expression	E. coli
Numéro d'accès	Q562E7
Longueur de protéine	Gly337-Gln614
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Espèces	Homo sapiens (Human)
Nature	Recombinant
Niveau d'endotoxines	Please contact with the lab for this information.
Pureté	>90% as determined by SDS-PAGE.
Masse moléculaire prédite	34.14 kDa
Forme	Lyophilized
Tampon de stockage	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Expédition	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stabilité et stockage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Noms alternatifs	WD repeat-containing protein 81, WDR81
Contexte	WD repeat-containing protein 81 is a ~211 kDa protein. Functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes via BECN1, a core subunit of the PI3K complex. By modifying the phosphatidylinositol 3-phosphate/PtdInsP3 content of endosomal membranes may regulate endosome fusion, recycling, sorting and early to late endosome transport. It is for instance, required for the delivery of cargos like BST2/tetherin from early to late endosome and thereby participates indirectly to their degradation by the lysosome. May also play a role in aggrephagy, the macroautophagic degradation of ubiquitinated protein aggregates. In this process, may regulate the interaction of SQSTM1 with ubiquitinated proteins and also recruit MAP1LC3C. 1. Liu, K. et al. (2016) The Journal of cell biology 212, 181-98. PMID: 26783301 2. Rapiteanu, R. et al. (2016) Traffic (Copenhagen, Denmark) 17, 940-58. PMID: 27126989 3. Liu, X. et al. (2017) The Journal of cell biology 216, 1301-1320. PMID: 28404643
Note	For research use only

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Human WDR81 Recombinant Protein (N-His).pdf

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