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Anti-Human WDR81 Polyclonal Antibody (HD280014)

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Overview
Catalog No.HD280014
Description
Anti-Human WDR81 Polyclonal Antibody (HD280014) is a rabbit polyclonal antibody detecting WDR81. Suitable for Human, Rat, and Mouse.
Highlights
  • ●Multi-Species — Cross-reactive for translational research.
Species reactivityHuman, Mouse, Rat
ApplicationsELISA, IHC, WB
Host speciesRabbit
IsotypeIgG
Clonality Polyclonal
Immunogen E. coli - derived recombinant Human WDR81 (Gly337-Gln614).
Target WD repeat-containing protein 81, WDR81
Endotoxin level Please contact with the lab for this information.
Purification Purified by antigen affinity column.
Accession Q562E7
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Background

WD repeat-containing protein 81 (WDR81) is a ~211 kDa protein. Functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes via BECN1, a core subunit of the PI3K complex. By modifying the phosphatidylinositol 3-phosphate/PtdInsP3 content of endosomal membranes may regulate endosome fusion, recycling, sorting and early to late endosome transport. It is for instance, required for the delivery of cargos like BST2/tetherin from early to late endosome and thereby participates indirectly to their degradation by the lysosome. May also play a role in aggrephagy, the macroautophagic degradation of ubiquitinated protein aggregates. In this process, may regulate the interaction of SQSTM1 with ubiquitinated proteins and also recruit MAP1LC3C.

1. Liu, K. et al. (2016) The Journal of cell biology 212, 181-98. PMID: 26783301
2. Rapiteanu, R. et al. (2016) Traffic (Copenhagen, Denmark) 17, 940-58. PMID: 27126989
3. Liu, X. et al. (2017) The Journal of cell biology 216, 1301-1320. PMID: 28404643
Note For research use only
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Datasheet
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Formula
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Anti-Human WDR81 Polyclonal Antibody

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