

| Numéro de catalogue | VK815012 |
|---|---|
| Description |
Recombinant MeV Non-structural protein V, N-His (VK815012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE..
Highlights
|
| Système d'expression | E. coli |
| Numéro d'accès | P0C774 |
| Longueur de protéine | Met1-Gly231 |
| Applications | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| Espèces | Measles virus (MeV) |
| Nature | Recombinant |
| Niveau d'endotoxines | Please contact with the lab for this information. |
| Pureté | >90% as determined by SDS-PAGE. |
| Forme | Lyophilized |
| Tampon de stockage | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot. |
| Reconstitution | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Expédition | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Stabilité et stockage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Noms alternatifs | Non-structural protein V, P/V |
| Contexte | Non-structural protein V is a ~32 kDa protein. Plays an essential role in the inhibition of host immune response. Prevents the establishment of cellular antiviral state by blocking interferon-alpha/beta (IFN-alpha/beta) production and signaling pathway. Interacts with host IFIH1/MDA5 and DHX58/LGP2 to inhibit the transduction pathway involved in the activation of IFN-beta promoter, thus protecting the virus against cell antiviral state. Blocks the type I interferon signaling pathway by interacting with host TYK2 and thereby inhibiting downstream STAT1 and STAT2 phosphorylation. Blocks the type I interferon signaling pathway by disrupting the RIG-I signaling pathway. 1. Takeuchi, K. et al. (2003) FEBS letters 545, 177-82. PMID: 12804771 2. Parisien, JP. et al. (2009) Journal of virology 83, 7252-60. PMID: 19403670 3. Ramachandran, A. et al. (2008) Journal of virology 82, 8330-8. PMID: 18579593 4. Chinnakannan, SK. et al. (2013) PloS one 8, e57063. PMID: 23431397 5. Davis, ME. et al. (2014) Cell host & microbe 16, 19-30. PMID: 25011105 |
| Note | For research use only |

SDS-PAGE for Recombinant MeV V/Non-structural protein V Protein, N-His
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