Anti-MeV Non-structural protein V Polyclonal Antibody (VK815014)

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Overview

Catalog No.

VK815014

Description

Anti-MeV Non-structural protein V Polyclonal Antibody (VK815014) is a rabbit polyclonal antibody detecting Non-structural protein V. Suitable for Measles virus.

Species reactivity

Measles virus

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant MeV Non-structural protein V (Met1-Gly231).

Target

Non-structural protein V, P/V

Endotoxin level

Please contact with the lab for this information.

Purification

Purified by antigen affinity column.

Accession

P0C774

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Background

Non-structural protein V is a ~32 kDa protein. Plays an essential role in the inhibition of host immune response. Prevents the establishment of cellular antiviral state by blocking interferon-alpha/beta (IFN-alpha/beta) production and signaling pathway. Interacts with host IFIH1/MDA5 and DHX58/LGP2 to inhibit the transduction pathway involved in the activation of IFN-beta promoter, thus protecting the virus against cell antiviral state. Blocks the type I interferon signaling pathway by interacting with host TYK2 and thereby inhibiting downstream STAT1 and STAT2 phosphorylation. Blocks the type I interferon signaling pathway by disrupting the RIG-I signaling pathway.

1. Takeuchi, K. et al. (2003) FEBS letters 545, 177-82. PMID: 12804771

2. Parisien, JP. et al. (2009) Journal of virology 83, 7252-60. PMID: 19403670

3. Ramachandran, A. et al. (2008) Journal of virology 82, 8330-8. PMID: 18579593

4. Chinnakannan, SK. et al. (2013) PloS one 8, e57063. PMID: 23431397

5. Davis, ME. et al. (2014) Cell host & microbe 16, 19-30. PMID: 25011105

Note

For research use only

Images

References

Datasheet

Anti-MeV Non-structural protein V Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-MeV Non-structural protein V Polyclonal Antibody (VK815014)

Overview

Images

References

Datasheet

SDS

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