MeV Non-structural V Recombinant Protein (N-His) (VK815012)

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Overview

Catalog No.	VK815012
Description	Recombinant MeV Non-structural protein V, N-His (VK815012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE.. Highlights ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% as determined by SDS-PAGE.
Expression system	E. coli
Accession	P0C774
Protein length	Met1-Gly231
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Measles virus (strain Ichinose-B95a) (MeV)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	Non-structural protein V, P/V
Background	Non-structural protein V is a ~32 kDa protein. Plays an essential role in the inhibition of host immune response. Prevents the establishment of cellular antiviral state by blocking interferon-alpha/beta (IFN-alpha/beta) production and signaling pathway. Interacts with host IFIH1/MDA5 and DHX58/LGP2 to inhibit the transduction pathway involved in the activation of IFN-beta promoter, thus protecting the virus against cell antiviral state. Blocks the type I interferon signaling pathway by interacting with host TYK2 and thereby inhibiting downstream STAT1 and STAT2 phosphorylation. Blocks the type I interferon signaling pathway by disrupting the RIG-I signaling pathway. 1. Takeuchi, K. et al. (2003) FEBS letters 545, 177-82. PMID: 12804771 2. Parisien, JP. et al. (2009) Journal of virology 83, 7252-60. PMID: 19403670 3. Ramachandran, A. et al. (2008) Journal of virology 82, 8330-8. PMID: 18579593 4. Chinnakannan, SK. et al. (2013) PloS one 8, e57063. PMID: 23431397 5. Davis, ME. et al. (2014) Cell host & microbe 16, 19-30. PMID: 25011105
Note	For research use only

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SDS-PAGE

SDS-PAGE for Recombinant MeV V/Non-structural protein V Protein, N-His

References

Datasheet

MeV Non-structural V Recombinant Protein (N-His).pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

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Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

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Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

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MeV Non-structural V Recombinant Protein (N-His) (VK815012)

Overview

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References

Datasheet

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