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| カタログ番号 | MB990012 |
|---|---|
| 説明 |
Recombinant Mouse CD119/IFNGR1 Protein, N-His (MB990012) expressed in E. coli, spanning Thr42-His248. Purity: >90% by SDS-PAGE.
Highlights
|
| 発現システム | E. coli |
| アクセッション番号 | P15261 |
| タンパク質長 | Thr42-His248 |
| アプリケーション | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 種 | Mus musculus (Mouse) |
| 性質 | Recombinant |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >90% as determined by SDS-PAGE. |
| 予測分子量 | 25.90 kDa |
| 形態 | Lyophilized |
| 保存バッファー | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 再構成 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 発送 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 別名 | CD119, CDw119, IFN-gamma receptor 1, IFN-gamma-R-alpha, IFN-gamma-R1, IFNGR1, Interferon gamma receptor 1, Interferon gamma receptor alpha-chain |
| 背景 | Interferon gamma receptor 1 is a ~52 kDa protein. Receptor subunit for interferon gamma/INFG that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation (, PubMed:20926559, PubMed:27286456). Associates with transmembrane accessory factor IFNGR2 to form a functional receptor. Upon ligand binding, the intracellular domain of IFNGR1 opens out to allow association of downstream signaling components JAK1 and JAK2. In turn, activated JAK1 phosphorylates IFNGR1 to form a docking site for STAT1. Subsequent phosphorylation of STAT1 leads to its dimerization, translocation to the nucleus, and stimulation of target gene transcription. 1. Kolokoltsova, OA. et al. (2010) Journal of virology 84, 13063-7. PMID: 20926559 2. Zhang, C. et al. (2016) Oncotarget 7, 42099-42109. PMID: 27286456 3. Cofano, F. et al. (1990) The Journal of biological chemistry 265, 4064-71. PMID: 2137461 4. Kumar, CS. et al. (1989) The Journal of biological chemistry 264, 17939-46. PMID: 2530216 5. Gray, PW. et al. (1989) Proceedings of the National Academy of Sciences of the United States of America 86, 8497-501. PMID: 2530582 6. Munro, S. et al. (1989) Proceedings of the National Academy of Sciences of the United States of America 86, 9248-52. PMID: 2531896 7. Hemmi, S. et al. (1989) Proceedings of the National Academy of Sciences of the United States of America 86, 9901-5. PMID: 2532365 8. Wei, B. et al. (2010) American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 10, 69-80. PMID: 19889125 9. Qing, Y. et al. (2004) The Journal of biological chemistry 279, 41679-85. PMID: 15284232 10. Qing, Y. et al. (2005) The Journal of biological chemistry 280, 1849-53. PMID: 15522878 |
| 注意事項 | For research use only |
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