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| カタログ番号 | MV277012 |
|---|---|
| 説明 |
Recombinant Mouse CD365/KIM-1/TIM-1/HAVCR1 Protein, C-His (MV277012) expressed in E. coli, spanning Tyr22-Gly237. Purity: >90% by SDS-PAGE.
Highlights
|
| 発現システム | E. coli |
| アクセッション番号 | Q5QNS5 |
| タンパク質長 | Tyr22-Gly237 |
| アプリケーション | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 種 | Mus musculus (Mouse) |
| 性質 | Recombinant |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >90% as determined by SDS-PAGE. |
| 予測分子量 | 25.93 kDa |
| 形態 | Lyophilized |
| 保存バッファー | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 再構成 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 発送 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 別名 | CD365, HAVCR1, HAVcr-1, Hepatitis A virus cellular receptor 1, KIM-1, KIM1, Kidney injury molecule 1, T-cell immunoglobulin and mucin domain-containing protein 1, T-cell immunoglobulin mucin receptor 1, T-cell membrane protein 1, TIM, TIM-1, TIM1, TIMD-1, TIMD1 |
| 背景 | Hepatitis A virus cellular receptor 1 homolog is a ~33 kDa protein. Phosphatidylserine receptor that plays an important functional role in regulatory B-cell homeostasis including generation, expansion and suppressor functions. As P-selectin/SELPLG ligand, plays a specialized role in activated but not naive T-cell trafficking during inflammatory responses. Controls thereby T-cell accumulation in the inflamed central nervous system (CNS) and the induction of autoimmune disease. Also regulates expression of various anti-inflammatory cytokines and co-inhibitory ligands including IL10. Acts as a regulator of T-cell proliferation. 1. Ding, Q. et al. (2011) The Journal of clinical investigation 121, 3645-56. PMID: 21821911 2. Yeung, MY. et al. (2015) American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 15, 942-53. PMID: 25645598 3. Xiao, S. et al. (2020) Cell reports 32, 107892. PMID: 32668241 4. Angiari, S. et al. (2014) Immunity 40, 542-53. PMID: 24703780 5. Xiao, S. et al. (2015) Journal of immunology (Baltimore, Md. : 1950) 194, 1602-8. PMID: 25582854 6. Meyers, JH. et al. (2005) Nature immunology 6, 455-64. PMID: 15793576 |
| 注意事項 | For research use only |
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