Recombinant Mouse CD366/HAVCR2/TIM-3 Protein, C-Fc (MV029011) expressed in Mammalian Cells, spanning Leu22-Arg191. Purity: >90% by SDS-PAGE.
Highlights
●Fc Fusion — Enhanced stability with Protein A/G purification compatibility.
●Mammalian Expression — Proper folding and native glycosylation.
●High Purity — >90% purity verified by SDS-PAGE.
Sistema de expresión
Mammalian cells
Número de acceso
Q3KP82
Longitud de proteína
Leu22-Arg191
Aplicaciones
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Especies
Mus musculus (Mouse)
Naturaleza
Recombinant
Objetivo
CD366, HAVCR2, HAVcr-2, Hepatitis A virus cellular receptor 2, T-cell immunoglobulin and mucin domain-containing protein 3, T-cell immunoglobulin mucin receptor 3, T-cell membrane protein 3, TIM-3, TIM3, TIMD-3, TIMD3
Nivel de endotoxinas
Please contact with the lab for this information.
Pureza
>90% as determined by SDS-PAGE.
Peso molecular predicho
47.22 kDa
Forma
Lyophilized
Buffer de almacenamiento
Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol.
Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Reconstitución
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Envío
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Estabilidad y almacenamiento
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Nombres alternativos
CD366, HAVCR2, HAVcr-2, Hepatitis A virus cellular receptor 2, T-cell immunoglobulin and mucin domain-containing protein 3, T-cell immunoglobulin mucin receptor 3, T-cell membrane protein 3, TIM-3, TIM3, TIMD-3, TIMD3
Fondo
Hepatitis A virus cellular receptor 2 homolog is a ~30 kDa protein. Cell surface receptor implicated in modulating innate and adaptive immune responses. Generally accepted to have an inhibiting function. Reports on stimulating functions suggest that the activity may be influenced by the cellular context and/or the respective ligand. Regulates macrophage activation. Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance.
1. Anderson, AC. et al. (2007) Science (New York, N.Y.) 318, 1141-3. PMID: 18006747
2. Monney, L. et al. (2002) Nature 415, 536-41. PMID: 11823861
3. Sabatos, CA. et al. (2003) Nature immunology 4, 1102-10. PMID: 14556006
4. Lee, J. et al. (2011) Molecular and cellular biology 31, 3963-74. PMID: 21807895
5. Rangachari, M. et al. (2012) Nature medicine 18, 1394-400. PMID: 22863785
6. Jayaraman, P. et al. (2010) The Journal of experimental medicine 207, 2343-54. PMID: 20937702
7. Gorman, JV. et al. (2014) Journal of immunology (Baltimore, Md. : 1950) 192, 3133-42. PMID: 24567532
8. DeKruyff, RH. et al. (2010) Journal of immunology (Baltimore, Md. : 1950) 184, 1918-30. PMID: 20083673
9. Nakayama, M. et al. (2009) Blood 113, 3821-30. PMID: 19224762
中文
English
한국어
日本語
Español
Français
Русский
