Mouse GFR alpha-like Recombinant Protein (N-GST & C-His) (MS720012)

Name: Mouse GFR alpha-like Recombinant Protein (N-GST & C-His)
Brand: abinScience
SKU: MS720012
Price: 211 USD
Availability: InStock

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Numéro de catalogue	MS720012
Description	Recombinant Mouse GFRAL Protein, N-GST & C-His (MS720012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE.. Highlights ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% as determined by SDS-PAGE.
Système d'expression	E. coli
Numéro d'accès	Q6SJE0
Longueur de protéine	Met128-Asn318
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Espèces	Mus musculus (Mouse)
Nature	Recombinant
Niveau d'endotoxines	Please contact with the lab for this information.
Pureté	>90% as determined by SDS-PAGE.
Forme	Lyophilized
Tampon de stockage	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Expédition	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stabilité et stockage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Noms alternatifs	GDNF family receptor alpha-like, Gfral, Gral
Contexte	GDNF family receptor alpha-like is a ~43 kDa protein. Brainstem-restricted receptor for GDF15 hormone, which triggers an aversive response, characterized by nausea, vomiting, and/or loss of appetite in response to various stresses. The aversive response is both required to reduce continuing exposure to those stresses at the time of exposure and to promote avoidance behavior in the future. The GDF15-GFRAL aversive response is triggered by stresses, such as anticancer drugs (camptothecin or cisplatin), cancers or drugs such as metformin. Upon interaction with its ligand, GDF15, mediates the GDF15-induced autophosphorylation and activation of the RET tyrosine kinase receptor, leading to activation of MAPK- and AKT- signaling pathways. Ligand-binding activates GFRAL-expressing neurons localized in the area postrema and nucleus tractus solitarius of the brainstem. 1. Mullican, SE. et al. (2017) Nature medicine 23, 1150-1157. PMID: 28846097 2. Emmerson, PJ. et al. (2017) Nature medicine 23, 1215-1219. PMID: 28846098 3. Yang, L. et al. (2017) Nature medicine 23, 1158-1166. PMID: 28846099 4. Hsu, JY. et al. (2017) Nature 550, 255-259. PMID: 28953886 5. Tsai, VW. et al. (2019) International journal of obesity (2005) 43, 2370-2380. PMID: 31152154 6. Borner, T. et al. (2020) Cell metabolism 31, 351-362.e5. PMID: 31928886 7. Worth, AA. et al. (2020) eLife 9. PMID: 32723474 8. Sabatini, PV. et al. (2021) Proceedings of the National Academy of Sciences of the United States of America 118. PMID: 33593916 9. Lu, JF. et al. (2022) PLoS biology 20, e3001517. PMID: 35202387 10. Benichou, O. et al. (2023) Cell metabolism 35, 274-286.e10. PMID: 36630958
Note	For research use only

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Mouse GFR alpha-like Recombinant Protein (N-GST & C-His).pdf

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