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Anti-Mouse GFR alpha-like Polyclonal Antibody (MS720014)

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Overview
Catalog No.MS720014
Description
Anti-Mouse GFRAL Polyclonal Antibody (MS720014) is a rabbit polyclonal antibody detecting Gfral. Suitable for Mouse and Rat.
Highlights
  • ●Multi-Species — Cross-reactive for translational research.
Species reactivityMouse, Rat
ApplicationsELISA, IHC, WB
Host speciesRabbit
IsotypeIgG
Clonality Polyclonal
Immunogen E. coli - derived recombinant Mouse GFRAL (Met128-Asn318).
Target GDNF family receptor alpha-like, Gfral, Gral
Endotoxin level Please contact with the lab for this information.
Purification Purified by antigen affinity column.
Accession Q6SJE0
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Background

GDNF family receptor alpha-like (GFRAL) is a ~43 kDa protein. Brainstem-restricted receptor for GDF15 hormone, which triggers an aversive response, characterized by nausea, vomiting, and/or loss of appetite in response to various stresses. The aversive response is both required to reduce continuing exposure to those stresses at the time of exposure and to promote avoidance behavior in the future. The GDF15-GFRAL aversive response is triggered by stresses, such as anticancer drugs (camptothecin or cisplatin), cancers or drugs such as metformin. Upon interaction with its ligand, GDF15, mediates the GDF15-induced autophosphorylation and activation of the RET tyrosine kinase receptor, leading to activation of MAPK- and AKT- signaling pathways. Ligand-binding activates GFRAL-expressing neurons localized in the area postrema and nucleus tractus solitarius of the brainstem.

1. Mullican, SE. et al. (2017) Nature medicine 23, 1150-1157. PMID: 28846097
2. Emmerson, PJ. et al. (2017) Nature medicine 23, 1215-1219. PMID: 28846098
3. Yang, L. et al. (2017) Nature medicine 23, 1158-1166. PMID: 28846099
4. Hsu, JY. et al. (2017) Nature 550, 255-259. PMID: 28953886
5. Tsai, VW. et al. (2019) International journal of obesity (2005) 43, 2370-2380. PMID: 31152154
6. Borner, T. et al. (2020) Cell metabolism 31, 351-362.e5. PMID: 31928886
7. Worth, AA. et al. (2020) eLife 9. PMID: 32723474
8. Sabatini, PV. et al. (2021) Proceedings of the National Academy of Sciences of the United States of America 118. PMID: 33593916
9. Lu, JF. et al. (2022) PLoS biology 20, e3001517. PMID: 35202387
10. Benichou, O. et al. (2023) Cell metabolism 35, 274-286.e10. PMID: 36630958
Note For research use only
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Formula
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Anti-Mouse GFR alpha-like Polyclonal Antibody

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