

| Каталожный номер | MX222012 |
|---|---|
| Описание |
Recombinant Mouse OAZ1 Protein, N-His (MX222012) expressed in E. coli, spanning Ser91-Asp227. Purity: >90% by SDS-PAGE.
Highlights
|
| Система экспрессии | E. coli |
| Номер доступа | P54369 |
| Длина белка | Ser91-Asp227 |
| Применения | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| Виды | Mus musculus (Mouse) |
| Характер | Recombinant |
| Уровень эндотоксинов | Please contact with the lab for this information. |
| Чистота | >90% as determined by SDS-PAGE. |
| Прогнозируемая молекулярная масса | 17.67 kDa |
| Форма | Lyophilized |
| Буфер хранения | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии. |
| Реконституция | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Доставка | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Устойчивость и хранение | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Альтернативные названия | AZ1, OAZ, OAZ1, ODC-Az, Ornithine decarboxylase antizyme 1 |
| Фон | Ornithine decarboxylase antizyme 1 is a ~25 kDa protein. Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimer, and targets the monomers for ubiquitin-independent proteolytic destruction by the 26S proteasome. Triggers ODC degradation by inducing the exposure of a cryptic proteasome-interacting surface of ODC. Stabilizes AZIN2 by interfering with its ubiquitination. Also inhibits cellular uptake of polyamines by inactivating the polyamine uptake transporter. 1. López-Contreras, AJ. et al. (2006) The Journal of biological chemistry 281, 30896-906. PMID: 16916800 2. López-Contreras, AJ. et al. (2008) The Journal of biological chemistry 283, 20761-9. PMID: 18508777 3. Snapir, Z. et al. (2008) The Biochemical journal 410, 613-9. PMID: 18062773 4. López-Contreras, AJ. et al. (2009) Journal of cellular biochemistry 107, 732-40. PMID: 19449338 |
| Примечание | For research use only |
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