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Anti-Mouse OAZ1 Polyclonal Antibody (MX222014)

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Overview
Catalog No.MX222014
Description
Anti-Mouse OAZ1 Polyclonal Antibody (MX222014) is a rabbit polyclonal antibody detecting OAZ1. Suitable for Rat and Mouse.
Highlights
  • ●Multi-Species — Cross-reactive for translational research.
Species reactivityMouse, Rat
ApplicationsELISA, IHC, WB
Host speciesRabbit
IsotypeIgG
Clonality Polyclonal
Immunogen E. coli - derived recombinant Mouse OAZ1 (Ser91-Asp227).
Target AZ1, OAZ, OAZ1, ODC-Az, Ornithine decarboxylase antizyme 1
Endotoxin level Please contact with the lab for this information.
Purification Purified by antigen affinity column.
Accession P54369
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Background

Ornithine decarboxylase antizyme 1 (OAZ1) is a ~25 kDa protein. Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimer, and targets the monomers for ubiquitin-independent proteolytic destruction by the 26S proteasome. Triggers ODC degradation by inducing the exposure of a cryptic proteasome-interacting surface of ODC. Stabilizes AZIN2 by interfering with its ubiquitination. Also inhibits cellular uptake of polyamines by inactivating the polyamine uptake transporter.

1. López-Contreras, AJ. et al. (2006) The Journal of biological chemistry 281, 30896-906. PMID: 16916800
2. López-Contreras, AJ. et al. (2008) The Journal of biological chemistry 283, 20761-9. PMID: 18508777
3. Snapir, Z. et al. (2008) The Biochemical journal 410, 613-9. PMID: 18062773
4. López-Contreras, AJ. et al. (2009) Journal of cellular biochemistry 107, 732-40. PMID: 19449338
Note For research use only
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Datasheet
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
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Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
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V₁ (Stock Vol.)
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Working Solution
C₂ (Working Conc.)
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V₂ (Working Vol.)
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Anti-Mouse OAZ1 Polyclonal Antibody

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