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| カタログ番号 | MS826011 |
|---|---|
| 説明 |
Recombinant Mouse SHH Protein, C-Fc (MS826011) expressed in Mammalian Cells, spanning Cys25-Gly198. Purity: >90% by SDS-PAGE.
Highlights
|
| 発現システム | Mammalian cells |
| アクセッション番号 | Q62226 |
| タンパク質長 | Cys25-Gly198 |
| アプリケーション | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 種 | Mus musculus (Mouse) |
| 性質 | Recombinant |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >90% as determined by SDS-PAGE. |
| 予測分子量 | 47.91 kDa |
| 形態 | Lyophilized |
| 保存バッファー | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 再構成 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 発送 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 別名 | EC:3.1.-.-, HHG-1, SHH, Shh N-terminal processed signaling domains, Shh unprocessed N-terminal signaling and C-terminal autoprocessing domains, ShhN, ShhNC, ShhNp, Sonic hedgehog protein, Sonic hedgehog protein N-product |
| 背景 | Sonic hedgehog protein is a ~47 kDa protein. The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity. Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN. Both activities occur in the reticulum endoplasmic. Once cleaved, ShhC is degraded in the endoplasmic reticulum. 1. Roelink, H. et al. (1995) Cell 81, 445-55. PMID: 7736596 2. Bumcrot, DA. et al. (1995) Molecular and cellular biology 15, 2294-303. PMID: 7891723 3. Porter, JA. et al. (1996) Science (New York, N.Y.) 274, 255-9. PMID: 8824192 4. Chen, X. et al. (2011) The Journal of cell biology 192, 825-38. PMID: 21357747 |
| 注意事項 | For research use only |
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