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| カタログ番号 | MP967022 |
|---|---|
| 説明 |
Recombinant Mouse TREML4 Protein, N-His (MP967022) expressed in E. coli, spanning Ser29-Pro138. Purity: >90% by SDS-PAGE.
Highlights
|
| 発現システム | E. coli |
| アクセッション番号 | Q3LRV9 |
| タンパク質長 | Ser29-Pro138 |
| アプリケーション | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 種 | Mus musculus (Mouse) |
| 性質 | Recombinant |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >90% as determined by SDS-PAGE. |
| 予測分子量 | 14.94 kDa |
| 形態 | Lyophilized |
| 保存バッファー | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 再構成 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 発送 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 別名 | TLT-4, TLT4, TREML4, Trem-like transcript 4 protein, Triggering receptor expressed on myeloid cells-like protein 4 |
| 背景 | Trem-like transcript 4 protein is a ~29 kDa protein. Positively regulates Toll-like receptor signaling via TLR7, TLR9 and TLR13 in neutrophils and splenic macrophages. Regulates TLR7 signaling by controlling ligand-induced recruitment of TLR7 from the endoplasmic reticulum to endosomes and lysosomes. Positively regulates Toll-like receptor TLR9-induced production of inflammatory cytokines but is dispensable for IFNB1 production. Involved in the anti-viral response to several viruses including influenza virus, vesicular stomatitis virus and cytomegalovirus. Binds to late apoptotic, and necrotic cells, but not living or early apoptotic cells, but is not essential for uptake of dying cells by dendritic cells (DCs). 1. Ramirez-Ortiz, ZG. et al. (2015) Nature immunology 16, 495-504. PMID: 25848864 2. Hemmi, H. et al. (2009) Journal of immunology (Baltimore, Md. : 1950) 182, 1278-86. PMID: 19155473 3. Hemmi, H. et al. (2012) Journal of immunology (Baltimore, Md. : 1950) 188, 1147-55. PMID: 22210914 |
| 注意事項 | For research use only |
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