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Anti-Mouse TREML4 Polyclonal Antibody (MP967014)

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Overview
Catalog No.MP967014
Species reactivityMouse
ApplicationsELISA, IHC, WB
Host speciesRabbit
IsotypeIgG
Clonality Polyclonal
Immunogen E. coli - derived recombinant Mouse TREML4 (Val31-Pro138).
Target Trem-like transcript 4 protein (TLT-4) (Triggering receptor expressed on myeloid cells-like protein 3) (Triggering receptor expressed on myeloid cells-like protein 4)
Purification Purified by antigen affinity column.
Accession Q3LRV9
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stability and Storage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background

Trem-like transcript 4 protein (TREML4) is a ~29 kDa protein. Positively regulates Toll-like receptor signaling via TLR7, TLR9 and TLR13 in neutrophils and splenic macrophages. Regulates TLR7 signaling by controlling ligand-induced recruitment of TLR7 from the endoplasmic reticulum to endosomes and lysosomes. Positively regulates Toll-like receptor TLR9-induced production of inflammatory cytokines but is dispensable for IFNB1 production. Involved in the anti-viral response to several viruses including influenza virus, vesicular stomatitis virus and cytomegalovirus. Binds to late apoptotic, and necrotic cells, but not living or early apoptotic cells, but is not essential for uptake of dying cells by dendritic cells (DCs).

1. Ramirez-Ortiz, ZG. et al. (2015) Nature immunology 16, 495-504. PMID: 25848864
2. Hemmi, H. et al. (2009) Journal of immunology (Baltimore, Md. : 1950) 182, 1278-86. PMID: 19155473
3. Hemmi, H. et al. (2012) Journal of immunology (Baltimore, Md. : 1950) 188, 1147-55. PMID: 22210914
Note For research use only.
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Formula
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Anti-Mouse TREML4 Polyclonal Antibody

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