Anti-Human PABPC1 Reference Antibody (Alextatug, RUO) (HY439016)

Name: Anti-Human PABPC1 Reference Antibody (Alextatug, RUO)
Brand: abinScience
SKU: HY439016
Price: 370 USD
Availability: InStock

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Aperçu

Numéro de catalogue	HY439016
Description	Alextatug (HY439016) is a research-grade recombinant antibody targeting PABP-1. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Reactivité des espèces	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Espèce hôte	Human
Clonalité	Monoclonal
Isotype	IgG1-lambda
Système d'expression	Mammalian cells
Cible	PABP-1, PAB1, PABPC2, PABPC1, Polyadenylate-binding protein 1, Poly(A)-binding protein 1, PABP1
Niveau d'endotoxines	< 10 EU/mg
Pureté	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Numéro d'accès	P11940
Forme	Liquid
Tampon de stockage	0.01M PBS pH 7.4 Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Stabilité et stockage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Noms alternatifs	2768264-93-1
Contexte	Polyadenylate-binding protein 1 (PABPC1) is a ~70 kDa protein. Binds the poly(A) tail of mRNA, including that of its own transcript, and regulates processes of mRNA metabolism such as pre-mRNA splicing and mRNA stability. Its function in translational initiation regulation can either be enhanced by PAIP1 or repressed by PAIP2. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo. Binds to N6-methyladenosine (m6A)-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs. Involved in translationally coupled mRNA turnover. 1. Grosset, C. et al. (2000) Cell 103, 29-40. PMID: 11051545 2. Patel, GP. et al. (2006) The FEBS journal 273, 5678-90. PMID: 17212783 3. Lim, J. et al. (2014) Cell 159, 1365-76. PMID: 25480299 4. Schäffler, K. et al. (2010) RNA (New York, N.Y.) 16, 1488-99. PMID: 20573744 5. Zhu, S. et al. (2020) Nature communications 11, 1685. PMID: 32245947 6. Singh, G. et al. (2008) PLoS biology 6, e111. PMID: 18447585
Note	For research use only. Not suitable for clinical or therapeutic use.
Isotype Control	Human IgG1, lambda Isotype Control antibody (HyHEL-10) (HP248107)

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SDS-PAGE for Research Grade Alextatug.

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Anti-Human PABPC1 Reference Antibody (Alextatug, RUO).pdf

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