Anti-Human ASGR1/ASGPR1 Reference Antibody (SBT8230, RUO) (HY525026)

Name: Anti-Human ASGR1/ASGPR1 Reference Antibody (SBT8230, RUO)
Brand: abinScience
SKU: HY525026
Price: 176 USD
Availability: InStock

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100ug
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Vista general

Número de catálogo	HY525026
Descripción	Anti-Human ASGR1 (SBT8230) (HY525026) is a research-grade recombinant antibody targeting HL-1. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Reactividad de especies	Human
Aplicaciones	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Especie huésped	Human
Clonalidad	Monoclonal
Isotipo	IgG1-kappa
ID de clon	SBT8230
Sistema de expresión	Mammalian cells
Objetivo	HL-1, ASGP-R 1, Asialoglycoprotein receptor 1, CLEC4H1, ASGR1, C-type lectin domain family 4 member H1, ASGPR 1, Hepatic lectin H1
Nivel de endotoxinas	< 10 EU/mg
Pureza	>95% purity as determined by SDS-PAGE.
Purificación	Protein A/G purified from cell culture supernatant.
Número de acceso	P07306
Forma	Liquid
Buffer de almacenamiento	0.01M PBS pH 7.4 Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Estabilidad y almacenamiento	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Nombres alternativos	SBT8230
Fondo	Asialoglycoprotein receptor 1 (ASGR1) is a ~33 kDa protein. Transmembrane protein predominantly expressed on hepatocytes that plays a key role in endocytosis of plasma glycoproteins that lack terminal sialic acid residues. Specifically recognizes terminal galactose and N-acetylgalactosamine residues, facilitating the clearance of desialylated glycoproteins from circulation. Plays thereby a role in a variety of physiological processes, such as removal of desialylated platelets, elimination of activated lymphocytes and maintenance of serum glycoprotein homeostasis. Plays a role in the removal of desialylated platelets by activating a feedback loop regulating thrombopoietin (TPO) expression via the JAK2-STAT3 signaling pathway. Contributes also to recognition and elimination of activated lymphocytes by hepatocytes that can act as cytotoxic effectors. 1. Grozovsky, R. et al. (2015) Nature medicine 21, 47-54. PMID: 25485912 2. Guy, CS. et al. (2011) Hepatology (Baltimore, Md.) 54, 1043-50. PMID: 21656538
Nota	For research use only. Not suitable for clinical or therapeutic use.
Isotype Control	Human IgG1 Recombinant Isotype Control Antibody (13R4) (HV080507)

Imágenes

SDS-PAGE

SDS-PAGE for Anti-Human ASGR1/ASGPR1 Reference Antibody (SBT8230, RUO)
Flow CytoMetry

Flow-cytometry using APC anti-human ASGR1 antibody. HepG-2 cells were stained with an irrelevant antibody (Blue Histogram) or an APC anti-human ASGR1 monoclonal antibody (Catalog: HY525026, Yellow Histogram) at a concentration of 5 µg/ml for 30 mins at RT. After washing, and cells analysed on a NovoCyte Flow Cytometer.
Flow CytoMetry

Flow-cytometry using FITC anti-human ASGR1 antibody. HepG-2 cells were stained with an irrelevant antibody (Blue Histogram) or an FITC anti-human ASGR1 monoclonal antibody (Catalog: HY525026, Yellow Histogram) at a concentration of 5 µg/ml for 30 mins at RT. After washing, and cells analysed on a NovoCyte Flow Cytometer.
Flow CytoMetry

Flow-cytometry using PE anti-human ASGR1 antibody. HepG-2 cells were stained with an irrelevant antibody (Blue Histogram) or an PE anti-human ASGR1 monoclonal antibody (Catalog: HY525026, Yellow Histogram) at a concentration of 5 µg/ml for 30 mins at RT. After washing, and cells analysed on a NovoCyte Flow Cytometer.