Anti-sLea/CA19-9 Reference Antibody (MVT-5873, RUO) (HP481016)

Name: Anti-sLea/CA19-9 Reference Antibody (MVT-5873, RUO)
Brand: abinScience
SKU: HP481016
Price: 176 USD
Availability: InStock

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Número de catálogo	HP481016
Reactividad de especies	Human
Aplicaciones	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Especie huésped	Human
Clonalidad	Monoclonal
Isotipo	IgG1
ID de clon	MVT-5873
Actividad biológica	Sialyl Lewis A mediates adhesion of human colon, pancreas, and gastric cancer cells to E-selectin-expressing endothelial cells, with complete abolition of this adhesion when Sialyl Lewis A expression is suppressed via antisense FT III cDNA transfection [1]. Sialyl Lewis A mediates adhesion of human urinary bladder cancer Hu 1703He cells to E-selectin-expressing CHO cells [1]. Sialyl Lewis A expression is required for the tumorigenicity of human squamous lung cancer cells in athymic nu/nu nude mice [1]. Sialyl Lewis A mediates nearly exclusive ELAM-1-dependent adhesion of Capan2, 2102Ep, QG90, Colo201, WiDr, and SW1116 human epithelial cancer cell lines to rIL1β-activated HUVECs [2]. Sialyl Lewis A is strongly expressed on the surface of Capan2, 2102Ep, QG90, Colo201, WiDr, and SW1116 human epithelial cancer cell lines, but is not detected on any of the 12 tested human leukemia cell lines [2]. Sialyl Lewis A does not contribute to the adhesion of any of the 12 tested human leukemia cell lines to rIL1β-activated HUVECs [2].
Sistema de expresión	Mammalian cells
Objetivo	CA19-9, Sialyl Lewis A, sLe A
Nivel de endotoxinas	< 10 EU/mg
Pureza	>95% purity as determined by SDS-PAGE.
Purificación	Protein A/G purified from cell culture supernatant.
Forma	Liquid
Buffer de almacenamiento	0.01M PBS pH 7.4 Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Estabilidad y almacenamiento	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Nombres alternativos	HuMab-5B1, MVT-5873
Referencias	1. Ugorski M, et al. Sialyl Lewis(a): a tumor-associated carbohydrate antigen involved in adhesion and metastatic potential of cancer cells. Acta Biochim Pol. 2002;49(2):303-311. [HP481016] 2. Takada A, et al. Contribution of carbohydrate antigens sialyl Lewis A and sialyl Lewis X to adhesion of human cancer cells to vascular endothelium. Cancer Res. 1993 Jan 15;53(2):354-61. [HP481016] 3. Ma Z, et al. Expression of the Carbohydrate Lewis Antigen, Sialyl Lewis A, Sialyl Lewis X, Lewis X, and Lewis Y in the Placental Villi of Patients With Unexplained Miscarriages. Front Immunol. 2021;12:679424. Published 2021 May 31. [HP481016]
Nota	For research use only. Not suitable for clinical or therapeutic use.