Anti-sLea/CA19-9 Reference Antibody (MVT-5873, RUO) (HP481016)

Name: Anti-sLea/CA19-9 Reference Antibody (MVT-5873, RUO)
Brand: abinScience
SKU: HP481016
Price: 176 USD
Availability: InStock

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Каталожный номер	HP481016
Реактивность видов	Human
Применения	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Хозяинский вид	Human
Клоональность	Monoclonal
Изотип	IgG1
ID клона	MVT-5873
Биологическая активность	Sialyl Lewis A mediates adhesion of human colon, pancreas, and gastric cancer cells to E-selectin-expressing endothelial cells, with complete abolition of this adhesion when Sialyl Lewis A expression is suppressed via antisense FT III cDNA transfection [1]. Sialyl Lewis A mediates adhesion of human urinary bladder cancer Hu 1703He cells to E-selectin-expressing CHO cells [1]. Sialyl Lewis A expression is required for the tumorigenicity of human squamous lung cancer cells in athymic nu/nu nude mice [1]. Sialyl Lewis A mediates nearly exclusive ELAM-1-dependent adhesion of Capan2, 2102Ep, QG90, Colo201, WiDr, and SW1116 human epithelial cancer cell lines to rIL1β-activated HUVECs [2]. Sialyl Lewis A is strongly expressed on the surface of Capan2, 2102Ep, QG90, Colo201, WiDr, and SW1116 human epithelial cancer cell lines, but is not detected on any of the 12 tested human leukemia cell lines [2]. Sialyl Lewis A does not contribute to the adhesion of any of the 12 tested human leukemia cell lines to rIL1β-activated HUVECs [2].
Система экспрессии	Mammalian cells
Цель	CA19-9, Sialyl Lewis A, sLe A
Уровень эндотоксинов	< 10 EU/mg
Чистота	>95% purity as determined by SDS-PAGE.
Очистка	Protein A/G purified from cell culture supernatant.
Форма	Liquid
Буфер хранения	0.01M PBS pH 7.4 Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.
Устойчивость и хранение	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Альтернативные названия	HuMab-5B1, MVT-5873
Ссылки	1. Ugorski M, et al. Sialyl Lewis(a): a tumor-associated carbohydrate antigen involved in adhesion and metastatic potential of cancer cells. Acta Biochim Pol. 2002;49(2):303-311. [HP481016] 2. Takada A, et al. Contribution of carbohydrate antigens sialyl Lewis A and sialyl Lewis X to adhesion of human cancer cells to vascular endothelium. Cancer Res. 1993 Jan 15;53(2):354-61. [HP481016] 3. Ma Z, et al. Expression of the Carbohydrate Lewis Antigen, Sialyl Lewis A, Sialyl Lewis X, Lewis X, and Lewis Y in the Placental Villi of Patients With Unexplained Miscarriages. Front Immunol. 2021;12:679424. Published 2021 May 31. [HP481016]
Примечание	For research use only. Not suitable for clinical or therapeutic use.