Anti-Human Thrombopoietin R/Tpo R Reference Antibody (TA136, RUO) (HW601016)

Name: Anti-Human Thrombopoietin R/Tpo R Reference Antibody (TA136, RUO)
Brand: abinScience
SKU: HW601016
Price: 370 USD
Availability: InStock

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Aperçu

Numéro de catalogue	HW601016
Description	Anti-Human CD110/MPL Antibody (TA136) (HW601016) is a research-grade recombinant antibody targeting CD110. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Reactivité des espèces	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Espèce hôte	Human
Isotype	IgG
ID de clone	TA136
Système d'expression	Mammalian cells
Cible	TPO-R, TPOR, Thrombopoietin receptor, MPL, Myeloproliferative leukemia protein, Proto-oncogene c-Mpl, CD110
Niveau d'endotoxines	< 10 EU/mg
Pureté	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Numéro d'accès	P40238
Forme	Liquid
Tampon de stockage	0.01M PBS pH 7.4 Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Stabilité et stockage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Noms alternatifs	TA136, TA136, TA-136
Contexte	Thrombopoietin receptor (CD110/MPL) is a ~71 kDa protein. Receptor for thrombopoietin that regulates hematopoietic stem cell renewal, megakaryocyte differentiation, and platelet formation. Upon activation by THPO, induces rapid tyrosine phosphorylation and activation of JAK2, providing docking sites for many signaling proteins such as STAT5, SHIP/INPP5D, GRB2, SOS1 and PI3K. In turn, These signaling cascades lead to the proliferation, survival, and differentiation of megakaryocytes, ultimately leading to increased platelet production. 1. Royer, Y. et al. (2005) The Journal of biological chemistry 280, 27251-61. PMID: 15899890 2. Tsutsumi, N. et al. (2023) Cell 186, 4189-4203.e22. PMID: 37633268
Note	For research use only. Not suitable for clinical or therapeutic use.

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SDS-PAGE

SDS-PAGE for Research Grade Anti-Human CD110/MPL Antibody (TA136)

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Anti-Human Thrombopoietin R/Tpo R Reference Antibody (TA136, RUO).pdf

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