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| カタログ番号 | HW601016 |
|---|---|
| 説明 |
Anti-Human CD110/MPL Antibody (TA136) (HW601016) is a research-grade recombinant antibody targeting CD110. Produced in mammalian cells with native-like glycosylation.
Highlights
|
| 種反応性 | Human |
| アプリケーション | ELISA, Bioactivity: FACS, Functional assay, Research in vivo |
| 宿主種 | Human |
| アイソタイプ | IgG |
| クローンID | TA136 |
| 発現システム | Mammalian cells |
| ターゲット | TPO-R, TPOR, Thrombopoietin receptor, MPL, Myeloproliferative leukemia protein, Proto-oncogene c-Mpl, CD110 |
| エンドトキシンレベル | < 10 EU/mg |
| 純度 | >95% purity as determined by SDS-PAGE. |
| 精製 | Protein A/G purified from cell culture supernatant. |
| アクセッション番号 | P40238 |
| 形態 | Liquid |
| 保存バッファー | 0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 別名 | TA136, TA136, TA-136 |
| 背景 | Thrombopoietin receptor (CD110/MPL) is a ~71 kDa protein. Receptor for thrombopoietin that regulates hematopoietic stem cell renewal, megakaryocyte differentiation, and platelet formation. Upon activation by THPO, induces rapid tyrosine phosphorylation and activation of JAK2, providing docking sites for many signaling proteins such as STAT5, SHIP/INPP5D, GRB2, SOS1 and PI3K. In turn, These signaling cascades lead to the proliferation, survival, and differentiation of megakaryocytes, ultimately leading to increased platelet production. 1. Royer, Y. et al. (2005) The Journal of biological chemistry 280, 27251-61. PMID: 15899890 2. Tsutsumi, N. et al. (2023) Cell 186, 4189-4203.e22. PMID: 37633268 |
| 注意事項 | For research use only. Not suitable for clinical or therapeutic use. |
SDS-PAGE for Research Grade Anti-Human CD110/MPL Antibody (TA136)
+86-027-65523339
中国武漢市深敦寺路666号C棟、武漢、430206
