Anti-Human IL-3R alpha/CD123 Reference Antibody (KHK2823, RUO) (HB714076)

Name: Anti-Human IL-3R alpha/CD123 Reference Antibody (KHK2823, RUO)
Brand: abinScience
SKU: HB714076
Price: 370 USD
Availability: InStock

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Número de catálogo	HB714076
Descripción	Anti-Human IL-3R alpha/CD123 Reference Antibody (KHK2823, RUO) (HB714076) is a human monoclonal antibody detecting IL-3R alpha/CD123. Expressed in Mammalian cells.
Reactividad de especies	Human
Aplicaciones	ELISA, Bioactivity: FCM, Functional assay, Research in vivo
Especie huésped	Human
Clonalidad	Monoclonal
Isotipo	IgG
ID de clon	KHK2823
Sistema de expresión	Mammalian cells
Naturaleza	Recombinant
Objetivo	IL-3R subunit alpha, IL-3 receptor subunit alpha, CD123, Interleukin-3 receptor subunit alpha, IL3R, IL-3R-alpha, IL3RA, IL-3RA
Nivel de endotoxinas	< 10 EU/mg as determined by LAL method.
Pureza	>95% as determined by SDS-PAGE.
Purificación	Protein A/G purified from cell culture supernatant.
Número de acceso	P26951
Forma	Liquid
Buffer de almacenamiento	0.01M PBS pH 7.4. Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Estabilidad y almacenamiento	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Nombres alternativos	KHK2823
Fondo	Interleukin-3 receptor subunit alpha (CD123/IL-3Rα) is a ~43 kDa protein. Cell surface receptor for IL3 expressed on hematopoietic progenitor cells, monocytes and B-lymphocytes that controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells. Ligand stimulation rapidly induces hetrodimerization with IL3RB, phosphorylation and enzyme activity of effector proteins such as JAK2 and PI3K that play a role in signaling cell proliferation and differentiation. Activation of JAK2 leads to STAT5-mediated transcriptional program. 1. Huang, S. et al. (1999) Stem cells (Dayton, Ohio) 17, 265-72. PMID: 10527461
Referencias	1. Manuel Ricardo Espinoza-Gutarra, et al. CD123-targeted therapy in acute myeloid leukemia. Expert Rev Hematol. 2021 Jun;14(6):561-576. [HB714076]
Nota	For research use only. Not suitable for clinical or therapeutic use.

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SDS-PAGE

SDS-PAGE for Research Grade Anti-Human CD123/IL3RA (KHK2823)

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Datasheet

Anti-Human IL-3R alpha/CD123 Reference Antibody (KHK2823, RUO).pdf

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Anti-Human IL-3R alpha/CD123 Reference Antibody (KHK2823, RUO) (HB714076)

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Datasheet

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