Anti-Human IL-3R alpha Reference Antibody (UCART123, RUO) (HB714056)

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100ug
1mg

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Overview

Catalog No.	HB714056
Description	Anti-Human CD123/IL3RA (UCART123) (HB714056) is a research-grade recombinant antibody targeting CD123. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Species reactivity	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Host species	Human
Isotype	IgG
Clone ID	UCART123
Expression system	Mammalian Cells
Clonality	Monoclonal
Target	IL-3R subunit alpha, IL-3 receptor subunit alpha, CD123, Interleukin-3 receptor subunit alpha, IL3R, IL-3R-alpha, IL3RA, IL-3RA
Endotoxin level	Please contact the lab for this information.
Purity	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	P26951
Form	Liquid
Storage buffer	0.01M PBS, pH 7.4. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	UCART123
Background	Interleukin-3 receptor subunit alpha (CD123/IL-3Rα) is a ~43 kDa protein. Cell surface receptor for IL3 expressed on hematopoietic progenitor cells, monocytes and B-lymphocytes that controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells. Ligand stimulation rapidly induces hetrodimerization with IL3RB, phosphorylation and enzyme activity of effector proteins such as JAK2 and PI3K that play a role in signaling cell proliferation and differentiation. Activation of JAK2 leads to STAT5-mediated transcriptional program. 1. Huang, S. et al. (1999) Stem cells (Dayton, Ohio) 17, 265-72. PMID: 10527461
Note	For research use only. Not suitable for clinical or therapeutic use.