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| カタログ番号 | HF985016 | ||||
|---|---|---|---|---|---|
| 説明 |
Anti-Human CD160 (MAT 303) (HF985016) is a research-grade recombinant antibody targeting CD160. Produced in mammalian cells with native-like glycosylation.
Highlights
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| 種反応性 | Human | ||||
| アプリケーション | ELISA, Bioactivity: FACS, Functional assay, Research in vivo | ||||
| 宿主種 | Human | ||||
| クローン性 | Monoclonal | ||||
| アイソタイプ | IgG | ||||
| クローンID | MAT 303 | ||||
| 発現システム | Mammalian cells | ||||
| ターゲット | Natural killer cell receptor BY55, CD160 antigen, CD160, BY55 | ||||
| エンドトキシンレベル | < 10 EU/mg | ||||
| 純度 | >95% purity as determined by SDS-PAGE. | ||||
| 精製 | Protein A/G purified from cell culture supernatant. | ||||
| アクセッション番号 | O95971 | ||||
| 形態 | Liquid | ||||
| 保存バッファー | 0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||
| 別名 | MAT-303, MAT303, MAT303 | ||||
| 背景 | CD160 antigen is a ~19 kDa protein. Receptor on immune cells capable to deliver stimulatory or inhibitory signals that regulate cell activation and differentiation. Exists as a GPI-anchored and as a transmembrane form, each likely initiating distinct signaling pathways via phosphoinositol 3-kinase in activated NK cells and via LCK and CD247/CD3 zeta chain in activated T cells. Receptor for both classical and non-classical MHC class I molecules. In the context of acute viral infection, recognizes HLA-C and triggers NK cell cytotoxic activity, likely playing a role in anti-viral innate immune response. On CD8+ T cells, binds HLA-A2-B2M in complex with a viral peptide and provides a costimulatory signal to activated/memory T cells. 1. Nikolova, M. et al. (2002) International immunology 14, 445-51. PMID: 11978774 2. Rabot, M. et al. (2007) International immunology 19, 401-9. PMID: 17307798 3. Giustiniani, J. et al. (2009) Journal of immunology (Baltimore, Md. : 1950) 182, 63-71. PMID: 19109136 4. Le Bouteiller, P. et al. (2002) Proceedings of the National Academy of Sciences of the United States of America 99, 16963-8. PMID: 12486241 5. Agrawal, S. et al. (1999) Journal of immunology (Baltimore, Md. : 1950) 162, 1223-6. PMID: 9973372 6. Viganò, S. et al. (2014) PLoS pathogens 10, e1004380. PMID: 25255144 7. Fons, P. et al. (2006) Blood 108, 2608-15. PMID: 16809620 8. Cai, G. et al. (2008) Nature immunology 9, 176-85. PMID: 18193050 | ||||
| 注意事項 | For research use only. Not suitable for clinical or therapeutic use. |
SDS-PAGE for Research Grade Anti-Human CD160 (MAT 303)
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中国武漢市深敦寺路666号C棟、武漢、430206
