Anti-Human SIRP alpha/CD172a Reference Antibody (CC-95251, RUO) (HX892066)

Name: Anti-Human SIRP alpha/CD172a Reference Antibody (CC-95251, RUO)
Brand: abinScience
SKU: HX892066
Price: 176 USD
Availability: InStock

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概要
イメージ
参考文献
データシート
SDS

概要

カタログ番号	HX892066
説明	Anti-Human CD172a/SIRPA (CC-95251) (HX892066) is a research-grade recombinant antibody targeting CD172. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
種反応性	Human
アプリケーション	ELISA, Bioactivity: FCM, Functional assay, Research in vivo
宿主種	Human
クローン性	Monoclonal
アイソタイプ	IgG
クローンID	CC-95251
テスト済みアプリケーション	WB
ターゲット	BIT, Bit, Brain Ig-like molecule with tyrosine-based activation motifs, CD172 antigen-like family member A, CD172a, Inhibitory receptor SHPS-1, MFR, MYD1, Macrophage fusion receptor, MyD-1 antigen, PTPNS1, SHP substrate 1, SHPS-1, SHPS1, SIRP, SIRPA, Signal-regulatory protein alpha-1, Signal-regulatory protein alpha-2, Signal-regulatory protein alpha-3, Sirp-alpha-1, Sirp-alpha-2, Sirp-alpha-3, Tyrosine-protein phosphatase non-receptor type substrate 1, p84
エンドトキシンレベル	< 10 EU/mg
純度	>95% as determined by SDS-PAGE.
精製	Protein A/G purified from cell culture supernatant.
アクセッション番号	P78324
形態	Liquid
保存バッファー	0.01M PBS pH 7.4. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。
安定性と保存	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
別名	CC-95251, CC95251, CC95251
背景	Tyrosine-protein phosphatase non-receptor type substrate 1 (CD172a/SIRPA) is a ~54 kDa protein. Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function. Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. 1. Yao, M. et al. (2014) Journal of the American Society of Nephrology : JASN 25, 1171-86. PMID: 24511121
注意事項	For research use only. Not suitable for clinical or therapeutic use.
Isotype Control	Human IgG1 Recombinant Isotype Control Antibody (13R4) (HV080507)

イメージ

SDS-PAGE

SDS-PAGE for Research Grade Anti-Human CD172a/SIRPA (CC-95251).
Western blot

Western blot analysis was performed using anti-CD172a/SIRPA monoclonal antibody at 1ug/mL on various samples.
Lane 1: recombinant human CD172a/SIRPA (Catalog No: HX892011)
Lane 2: negative control
Bioactivity

Detects recombinant CD172a (Catalog No: HX892011) in indirect ELISA.