

| Каталожный номер | HW444036 | ||||
|---|---|---|---|---|---|
| Описание |
Anti-Human CD198/CCR8 (SRF114) (HW444036) is a research-grade recombinant antibody targeting CKR-L1. Produced in mammalian cells with native-like glycosylation.
Highlights
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| Реактивность видов | Human | ||||
| Применения | ELISA, Bioactivity: FACS, Functional assay, Research in vivo | ||||
| Хозяинский вид | Human | ||||
| Клоональность | Monoclonal | ||||
| Изотип | IgG1, kappa | ||||
| ID клона | SRF114 | ||||
| Система экспрессии | Mammalian cells | ||||
| Цель | CKR-L1, CMKBR8, C-C CKR-8, GPR-CY6, CCR8, CMKBRL2, TER1, CCR-8, Chemokine receptor-like 1, CKRL1, CDw198, GPRCY6, C-C chemokine receptor type 8, CC-CKR-8, CC chemokine receptor CHEMR1 | ||||
| Уровень эндотоксинов | < 10 EU/mg | ||||
| Чистота | >95% purity as determined by SDS-PAGE. | ||||
| Очистка | Protein A/G purified from cell culture supernatant. | ||||
| Номер доступа | P51685 | ||||
| Форма | Liquid | ||||
| Буфер хранения | 0.01M PBS pH 7.4 Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии. |
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| Информация об использовании продукта |
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| Устойчивость и хранение | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||
| Фон | C-C chemokine receptor type 8 (CD198/CCR8) is a ~40 kDa protein. G protein-coupled receptor that can bind a variety of chemokines, such as CCL1, CCL8, CCL16, CCL18. Regulates monocyte and eosinophil chemotaxis. Undergoes internalization upon CCL18 binding, leading to induced migration and calcium flux of highly polarized Th2 cells. In microglial cells, promotes phagocytosis with CCL18 through NF-kappa-B and Src signaling pathways. Stimulation of the CCL1-CCR8 signaling axis protects the gut from acute intestinal damage. 1. Islam, SA. et al. (2013) The Journal of experimental medicine 210, 1889-98. PMID: 23999500 2. Ding, D. et al. (2022) Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 42, 19-28. PMID: 35041514 | ||||
| Примечание | For research use only. Not suitable for clinical or therapeutic use. |

SDS-PAGE for Research Grade Anti-Human CD198/CCR8 (SRF114)




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