Anti-Human CDCP1 Reference Antibody (RG7287, RUO) (HV451016)

Name: Anti-Human CDCP1 Reference Antibody (RG7287, RUO)
Brand: abinScience
SKU: HV451016
Price: 176 USD
Availability: InStock

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Aperçu
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Reférences
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SDS

Aperçu

Numéro de catalogue	HV451016
Reactivité des espèces	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Espèce hôte	Human
Clonalité	Monoclonal
Isotype	IgG1-kappa
ID de clone	RG7287
Système d'expression	Mammalian cells
Cible	CD318, Transmembrane and associated with src kinases, TRASK, Subtractive immunization M plus HEp3-associated 135 kDa protein, SIMA135, Membrane glycoprotein gp140, CUB domain-containing protein 1, CDCP1
Niveau d'endotoxines	< 10 EU/mg
Pureté	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Numéro d'accès	Q9H5V8
Forme	Liquid
Tampon de stockage	0.01M PBS pH 7.4 Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Stabilité et stockage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Noms alternatifs	RG7287
Contexte	CUB domain-containing protein 1 (CD318/CDCP1) is a ~92 kDa protein. May be involved in cell adhesion and cell matrix association. May play a role in the regulation of anchorage versus migration or proliferation versus differentiation via its phosphorylation. May be a novel marker for leukemia diagnosis and for immature hematopoietic stem cell subsets. Belongs to the tetraspanin web involved in tumor progression and metastasis.
Reférences	1. Gwendlyn Kollmorgen, et al. Antibody mediated CDCP1 degradation as mode of action for cancer targeted therapy. Mol Oncol. 2013 Dec;7(6):1142-51. [HV451016]
Note	For research use only. Not suitable for clinical or therapeutic use.
Isotype Control	Human IgG1 Recombinant Isotype Control Antibody (13R4) (HV080507)

Images

Bioactivity

Detects CD318 in indirect ELISA.
SDS-PAGE

SDS-PAGE for Research Grade Anti-Human CD318/CDCP1 (RG7287).
Flow CytoMetry

Flow-cytometry using APC anti-human CD318 antibody. HT-29 cells were stained with an irrelevant antibody (Blue Histogram) or an APC anti-human CD318 monoclonal antibody (Catalog: HV451016, Yellow Histogram) at a concentration of 5 µg/ml for 30 mins at RT. After washing, cells analysed on a NovoCyte Flow Cytometer.
Flow CytoMetry

Flow-cytometry using PE anti-human CD318 antibody. HT-29 cells were stained with an irrelevant antibody (Blue Histogram) or an PE anti-human CD318 monoclonal antibody (Catalog: HV451016, Yellow Histogram) at a concentration of 5 µg/ml for 30 mins at RT. After washing, cells analysed on a NovoCyte Flow Cytometer.
Flow cytometry

Flow-cytometry using anti-human CD318 antibody. HT29 cells were stained with an irrelevant antibody (Blue Histogram) or an anti-human CD318 monoclonal antibody (Catalog HV451016, Yellow Histogram) at a concentration of 5 µg/ml for 30 mins at RT. After washing, bound antibody was detected using a Goat Anti-Human IgG H&L Polyclonal Antibody, FITC (abinScience: HF690414) and cells analysed on a NovoCyte Flow Cytometer.