Anti-Human MICL/CLEC12A Reference Antibody (H6e7, RUO) (HV493036)

Name: Anti-Human MICL/CLEC12A Reference Antibody (H6e7, RUO)
Brand: abinScience
SKU: HV493036
Price: 176 USD
Availability: InStock

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概要

カタログ番号	HV493036
説明	Anti-Human CD371/CLEC12A Antibody (H6e7) (HV493036) is a research-grade recombinant antibody targeting CD371. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
種反応性	Human
アプリケーション	ELISA, Bioactivity: FCM, Functional assay, Research in vivo
宿主種	Human
クローン性	Monoclonal
アイソタイプ	IgG1
クローンID	H6e7
発現システム	Mammalian cells
性質	Recombinant
ターゲット	CLEC12A, DCAL2, Dendritic cell-associated lectin 2, CLL-1, Myeloid inhibitory C-type lectin-like receptor, C-type lectin domain family 12 member A, CLL1, DCAL-2, C-type lectin-like molecule 1, MICL, CD371
エンドトキシンレベル	< 10 EU/mg as determined by LAL method.
純度	>95% as determined by SDS-PAGE.
精製	Protein A/G purified from cell culture supernatant.
アクセッション番号	Q5QGZ9
形態	Liquid
保存バッファー	0.01M PBS pH 7.4. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。
安定性と保存	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景	C-type lectin domain family 12 member A (CD371/CLEC12A) is a ~30 kDa protein. Myeloid inhibitory C-type lectin receptor that acts as a negative regulator of myeloid cell activation. Myeloid cell inhibition is required to limit proinflammatory pathways and protect against excessive inflammation. Specifically recognizes and binds various structures, such as neutrophil extracellular traps (NETs) or monosodium urate crystals. Also acts as a pattern-recognition receptor for pathogen-associated molecules, such as plasmodium hemozoin or mycobacterial micolic acid. Ligand-binding induces phosphorylation of its ITIM motif, followed by recruitment of tyrosine-protein phosphatases PTPN6 and PTPN11, which counteract tyrosine-protein kinase SYK, thereby preventing myeloid cell activation. 1. Marshall, AS. et al. (2004) The Journal of biological chemistry 279, 14792-802. PMID: 14739280 2. Han, Y. et al. (2004) Blood 104, 2858-66. PMID: 15238421 3. Chen, CH. et al. (2006) Blood 107, 1459-67. PMID: 16239426 4. Paré, G. et al. (2021) Frontiers in immunology 12, 650808. PMID: 34234773 5. Tang, H. et al. (2024) The Journal of biological chemistry 300, 105765. PMID: 38367667 6. Mori, S. et al. (2024) International immunology 36, 279-290. PMID: 38386511 7. Malamud, M. et al. (2024) Nature 633, 442-450. PMID: 39143217
注意事項	For research use only. Not suitable for clinical or therapeutic use.
Isotype Control	Human IgG1 Recombinant Isotype Control Antibody (13R4) (HV080507)

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SDS-PAGE for Research Grade Anti-Human CD371/CLEC12A Antibody (H6e7)

参考文献

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Anti-Human MICL/CLEC12A Reference Antibody (H6e7, RUO).pdf

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Anti-Human MICL/CLEC12A Reference Antibody (H6e7, RUO) (HV493036)

概要

イメージ

参考文献

データシート

SDS