Anti-Human MICL/CLEC12A Reference Antibody (H6e7, RUO) (HV493036)

Name: Anti-Human MICL/CLEC12A Reference Antibody (H6e7, RUO)
Brand: abinScience
SKU: HV493036
Price: 176 USD
Availability: InStock

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100ug
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Каталожный номер	HV493036
Описание	Anti-Human CD371/CLEC12A Antibody (H6e7) (HV493036) is a research-grade recombinant antibody targeting CD371. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Реактивность видов	Human
Применения	ELISA, Bioactivity: FCM, Functional assay, Research in vivo
Хозяинский вид	Human
Клоональность	Monoclonal
Изотип	IgG1
ID клона	H6e7
Система экспрессии	Mammalian cells
Характер	Recombinant
Цель	CLEC12A, DCAL2, Dendritic cell-associated lectin 2, CLL-1, Myeloid inhibitory C-type lectin-like receptor, C-type lectin domain family 12 member A, CLL1, DCAL-2, C-type lectin-like molecule 1, MICL, CD371
Уровень эндотоксинов	< 10 EU/mg as determined by LAL method.
Чистота	>95% as determined by SDS-PAGE.
Очистка	Protein A/G purified from cell culture supernatant.
Номер доступа	Q5QGZ9
Форма	Liquid
Буфер хранения	0.01M PBS pH 7.4. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.
Устойчивость и хранение	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Фон	C-type lectin domain family 12 member A (CD371/CLEC12A) is a ~30 kDa protein. Myeloid inhibitory C-type lectin receptor that acts as a negative regulator of myeloid cell activation. Myeloid cell inhibition is required to limit proinflammatory pathways and protect against excessive inflammation. Specifically recognizes and binds various structures, such as neutrophil extracellular traps (NETs) or monosodium urate crystals. Also acts as a pattern-recognition receptor for pathogen-associated molecules, such as plasmodium hemozoin or mycobacterial micolic acid. Ligand-binding induces phosphorylation of its ITIM motif, followed by recruitment of tyrosine-protein phosphatases PTPN6 and PTPN11, which counteract tyrosine-protein kinase SYK, thereby preventing myeloid cell activation. 1. Marshall, AS. et al. (2004) The Journal of biological chemistry 279, 14792-802. PMID: 14739280 2. Han, Y. et al. (2004) Blood 104, 2858-66. PMID: 15238421 3. Chen, CH. et al. (2006) Blood 107, 1459-67. PMID: 16239426 4. Paré, G. et al. (2021) Frontiers in immunology 12, 650808. PMID: 34234773 5. Tang, H. et al. (2024) The Journal of biological chemistry 300, 105765. PMID: 38367667 6. Mori, S. et al. (2024) International immunology 36, 279-290. PMID: 38386511 7. Malamud, M. et al. (2024) Nature 633, 442-450. PMID: 39143217
Примечание	For research use only. Not suitable for clinical or therapeutic use.
Isotype Control	Human IgG1 Recombinant Isotype Control Antibody (13R4) (HV080507)

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SDS-PAGE for Research Grade Anti-Human CD371/CLEC12A Antibody (H6e7)

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Anti-Human MICL/CLEC12A Reference Antibody (H6e7, RUO).pdf

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Anti-Human MICL/CLEC12A Reference Antibody (H6e7, RUO) (HV493036)

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