Anti-Human Dkk-1 Reference Antibody (PF-04840082, RUO) (HF914036)

Name: Anti-Human Dkk-1 Reference Antibody (PF-04840082, RUO)
Brand: abinScience
SKU: HF914036
Price: 370 USD
Availability: InStock

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Número de catálogo	HF914036
Descripción	Anti-Human Dkk-1 Reference Antibody (PF-04840082, RUO) (HF914036) is a human monoclonal antibody detecting Dkk-1. Expressed in Mammalian cells.
Reactividad de especies	Human
Aplicaciones	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Especie huésped	Human
Clonalidad	Monoclonal
Isotipo	IgG2
ID de clon	PF-04840082
Sistema de expresión	Mammalian cells
Objetivo	Dickkopf-1, SK, hDkk-1, Dkk-1, Dickkopf-related protein 1, DKK1
Nivel de endotoxinas	< 10 EU/mg
Pureza	>95% purity as determined by SDS-PAGE.
Purificación	Protein A/G purified from cell culture supernatant.
Número de acceso	O94907
Forma	Liquid
Buffer de almacenamiento	0.01M PBS pH 7.4 Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Estabilidad y almacenamiento	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Nombres alternativos	PF-04840082, PF04840082, PF04840082, RN-564, RN564, RN564
Fondo	Dickkopf-related protein 1 (DKK1) is a ~28 kDa protein. Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease. Inhibits the pro-apoptotic function of KREMEN1 in a Wnt-independent manner, and has anti-apoptotic activity. 1. Ahn, VE. et al. (2011) Developmental cell 21, 862-73. PMID: 22000856 2. Niehrs, C. (2006) Oncogene 25, 7469-81. PMID: 17143291
Referencias	1. Betts AM, et al. The application of target information and preclinical pharmacokinetic/pharmacodynamic modeling in predicting clinical doses of a Dickkopf-1 antibody for osteoporosis. J Pharmacol Exp Ther. 2010 Apr;333(1):2-13. [HF914036] 2. Kovács B, et al. The Wnt Signalling Pathways: A Short Review and Specific Roles in Bone Biochemistry[J]. Acta Medica Marisiensis, 2017, 63(3). [HF914036]
Nota	For research use only. Not suitable for clinical or therapeutic use.