Anti-Human Dkk-1 Recombinant Nanobody (SAA1268) (HF914013)

Name: Anti-Human Dkk-1 Recombinant Nanobody (SAA1268)
Brand: abinScience
SKU: HF914013
Price: 191 USD
Availability: InStock

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100ug
1mg

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Overview
Images
References
Datasheet
SDS

Overview

Catalog No.

HF914013

Description

Anti-Human DKK1 Nanobody (SAA1268) [SAA1268] (HF914013) is a alpaca monoclonal antibody detecting DKK1 in ELISA. Suitable for Human.

Species reactivity

Human

Applications

ELISA

Host species

Alpaca

Clonality

Monoclonal

Isotype

VHH-8His-Cys-tag

Clone ID

SAA1268

Target

Dickkopf-1, SK, hDkk-1, Dkk-1, Dickkopf-related protein 1, DKK1

Endotoxin level

< 10 EU/mg as determined by LAL method.

Purity

>95% as determined by SDS-PAGE.

Purification

Purified by Nickel column.

Accession

O94907

Form

Liquid

Storage buffer

0.01M PBS pH 7.4.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:2000-1:20000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Dickkopf-related protein 1 (DKK1) is a ~28 kDa protein. Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease. Inhibits the pro-apoptotic function of KREMEN1 in a Wnt-independent manner, and has anti-apoptotic activity.

1. Ahn, VE. et al. (2011) Developmental cell 21, 862-73. PMID: 22000856

2. Niehrs, C. (2006) Oncogene 25, 7469-81. PMID: 17143291

Note

For research use only.

Images

SDS-PAGE

SDS-PAGE for Anti-Human DKK1 Nanobody (SAA1268)
Bioactivity

Detects recombinant DKK3 (Catalog No: HF914011) in indirect ELISA.

References

Datasheet

Anti-Human Dkk-1 Recombinant Nanobody (SAA1268).pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Human Dkk-1 Recombinant Nanobody (SAA1268) (HF914013)

Overview

Images

References

Datasheet

SDS