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| カタログ番号 | HB152016 |
|---|---|
| 説明 |
Anti-Human EPOR (rhEPO-Fc) (HB152016) is a research-grade recombinant antibody targeting EPOR. Produced in mammalian cells with native-like glycosylation.
Highlights
|
| 種反応性 | Human |
| アプリケーション | Functional assay |
| 宿主種 | Human |
| 発現システム | Mammalian cells |
| 種 | Homo sapiens (Human) |
| ターゲット | EPOR, Erythropoietin receptor, EPO-R |
| エンドトキシンレベル | < 10 EU/mg |
| 純度 | >95% purity as determined by SDS-PAGE. |
| 精製 | Protein A/G purified from cell culture supernatant. |
| アクセッション番号 | P01588 |
| 形態 | Liquid |
| 保存バッファー | 0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 背景 | Erythropoietin receptor (EPOR) is a ~55 kDa protein. Receptor for erythropoietin, which mediates erythropoietin-induced erythroblast proliferation and differentiation. Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade. In some cell types, can also activate STAT1 and STAT3. May also activate the LYN tyrosine kinase. _x005F_x005F_x000D_ _x005F_x005F_x000D_1. Zhan, H. et al. (1999) Protein engineering 12, 505-13. PMID: 10388848 _x005F_x005F_x000D_
_x005F_x005F_x000D_
2. Winkelmann, JC. et al. (1990) Blood 76, 24-30. PMID: 2163695 _x005F_x005F_x000D_
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3. Jones, SS. et al. (1990) Blood 76, 31-5. PMID: 2163696 _x005F_x005F_x000D_
_x005F_x005F_x000D_
4. Middleton, SA. et al. (1996) The Journal of biological chemistry 271, 14045-54. PMID: 8662939 _x005F_x005F_x000D_
_x005F_x005F_x000D_
5. Syed, RS. et al. (1998) Nature 395, 511-6. PMID: 9774108 _x005F_x005F_x000D_
_x005F_x005F_x000D_
6. Kirito, K. et al. (2002) Blood 99, 102-10. PMID: 11756159 _x005F_x005F_x000D_ |
| 注意事項 | For research use only. Not suitable for clinical or therapeutic use. |
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