Anti-Human Ferroportin/SLC40A1 Reference Antibody (LY2928057, RUO) (HV370016)

Name: Anti-Human Ferroportin/SLC40A1 Reference Antibody (LY2928057, RUO)
Brand: abinScience
SKU: HV370016
Price: 192 USD
Availability: InStock

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Número de catálogo	HV370016
Descripción	Anti-Human FPN1/SLC40A1/Ferroportin (LY2928057) (HV370016) is a research-grade recombinant antibody targeting Solute carrier family 40 member 1. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Reactividad de especies	Human
Aplicaciones	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Especie huésped	Human
Clonalidad	Monoclonal
Isotipo	IgG
ID de clon	LY2928057
Sistema de expresión	Mammalian cells
Objetivo	Solute carrier family 40 member 1, SLC11A3, FPN1, SLC40A1, Iron-regulated transporter 1, IREG1, Ferroportin-1
Nivel de endotoxinas	< 10 EU/mg
Pureza	>95% purity as determined by SDS-PAGE.
Purificación	Protein A/G purified from cell culture supernatant.
Número de acceso	Q9NP59
Forma	Liquid
Buffer de almacenamiento	0.01M PBS pH 7.4 Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Estabilidad y almacenamiento	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Nombres alternativos	LY2928057
Fondo	Ferroportin (FPN1/SLC40A1) is a ~62 kDa protein. Transports Fe(2+) from the inside of a cell to the outside of the cell, playing a key role for maintaining systemic iron homeostasis. Transports iron from intestinal, splenic, hepatic cells, macrophages and erythrocytes into the blood to provide iron to other tissues. Controls therefore dietary iron uptake, iron recycling by macrophages and erythrocytes, and release of iron stores in hepatocytes. When iron is in excess in serum, circulating HAMP/hepcidin levels increase resulting in a degradation of SLC40A1, thus limiting the iron efflux to plasma. 1. Schimanski, LM. et al. (2005) Blood 105, 4096-102. PMID: 15692071 2. Madejczyk, MS. et al. (2012) Biochimica et biophysica acta 1818, 651-7. PMID: 22178646 3. Qiao, B. et al. (2012) Cell metabolism 15, 918-24. PMID: 22682227 4. Mitchell, CJ. et al. (2014) American journal of physiology. Cell physiology 306, C450-9. PMID: 24304836 5. Aschemeyer, S. et al. (2018) Blood 131, 899-910. PMID: 29237594 6. Zhang, DL. et al. (2018) Science (New York, N.Y.) 359, 1520-1523. PMID: 29599243 7. Choi, EK. et al. (2019) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 33, 2228-2240. PMID: 30247984 8. Billesbølle, CB. et al. (2020) Nature 586, 807-811. PMID: 32814342
Nota	For research use only. Not suitable for clinical or therapeutic use.

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SDS-PAGE

SDS-PAGE for Research Grade Anti-Human FPN1/SLC40A1/Ferroportin (LY2928057)

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Datasheet

Anti-Human Ferroportin/SLC40A1 Reference Antibody (LY2928057, RUO).pdf

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