中文
English
한국어
日本語
Español
Français
Русский
| カタログ番号 | HV370016 |
|---|---|
| 説明 |
Anti-Human FPN1/SLC40A1/Ferroportin (LY2928057) (HV370016) is a research-grade recombinant antibody targeting Solute carrier family 40 member 1. Produced in mammalian cells with native-like glycosylation.
Highlights
|
| 種反応性 | Human |
| アプリケーション | ELISA, Bioactivity: FACS, Functional assay, Research in vivo |
| 宿主種 | Human |
| クローン性 | Monoclonal |
| アイソタイプ | IgG |
| クローンID | LY2928057 |
| 発現システム | Mammalian cells |
| ターゲット | Solute carrier family 40 member 1, SLC11A3, FPN1, SLC40A1, Iron-regulated transporter 1, IREG1, Ferroportin-1 |
| エンドトキシンレベル | < 10 EU/mg |
| 純度 | >95% purity as determined by SDS-PAGE. |
| 精製 | Protein A/G purified from cell culture supernatant. |
| アクセッション番号 | Q9NP59 |
| 形態 | Liquid |
| 保存バッファー | 0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 別名 | LY2928057 |
| 背景 | Ferroportin (FPN1/SLC40A1) is a ~62 kDa protein. Transports Fe(2+) from the inside of a cell to the outside of the cell, playing a key role for maintaining systemic iron homeostasis. Transports iron from intestinal, splenic, hepatic cells, macrophages and erythrocytes into the blood to provide iron to other tissues. Controls therefore dietary iron uptake, iron recycling by macrophages and erythrocytes, and release of iron stores in hepatocytes. When iron is in excess in serum, circulating HAMP/hepcidin levels increase resulting in a degradation of SLC40A1, thus limiting the iron efflux to plasma. 1. Schimanski, LM. et al. (2005) Blood 105, 4096-102. PMID: 15692071 2. Madejczyk, MS. et al. (2012) Biochimica et biophysica acta 1818, 651-7. PMID: 22178646 3. Qiao, B. et al. (2012) Cell metabolism 15, 918-24. PMID: 22682227 4. Mitchell, CJ. et al. (2014) American journal of physiology. Cell physiology 306, C450-9. PMID: 24304836 5. Aschemeyer, S. et al. (2018) Blood 131, 899-910. PMID: 29237594 6. Zhang, DL. et al. (2018) Science (New York, N.Y.) 359, 1520-1523. PMID: 29599243 7. Choi, EK. et al. (2019) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 33, 2228-2240. PMID: 30247984 8. Billesbølle, CB. et al. (2020) Nature 586, 807-811. PMID: 32814342 |
| 注意事項 | For research use only. Not suitable for clinical or therapeutic use. |
SDS-PAGE for Research Grade Anti-Human FPN1/SLC40A1/Ferroportin (LY2928057)
+86-027-65523339
中国武漢市深敦寺路666号C棟、武漢、430206
