Anti-Human Hepcidin Reference Antibody (LY2787106, RUO) (HX911016)

Name: Anti-Human Hepcidin Reference Antibody (LY2787106, RUO)
Brand: abinScience
SKU: HX911016
Price: 370 USD
Availability: InStock

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Precio(USD):

Especificación:

100ug
1mg
5mg
10mg
25mg
50mg
100mg

Número:

Contáctenos

Vista general
Imágenes
Referencias
Datasheet
SDS

Vista general

Número de catálogo

HX911016

Descripción

Anti-Human HAMP/Hepcidin (LY2787106) (HX911016) is a research-grade recombinant antibody targeting Putative liver tumor regressor. Produced in mammalian cells with native-like glycosylation.

Highlights

●Research Grade — For PK/PD studies, assay development, and ADA research.
●Native Glycosylation — Mammalian expression ensures native-like patterns.

Reactividad de especies

Human

Aplicaciones

ELISA, Bioactivity: FCM, Functional assay, Research in vivo, WB

Especie huésped

Human

Clonalidad

Monoclonal

Isotipo

IgG

ID de clon

LY2787106

Sistema de expresión

Mammalian cells

Aplicaciones probadas

Objetivo

Putative liver tumor regressor, HEPC, LEAP-1, Liver-expressed antimicrobial peptide 1, PLTR, Hepcidin, LEAP1, Hepc25, Hepc20, HAMP

Nivel de endotoxinas

< 10 EU/mg

Pureza

>95% as determined by SDS-PAGE.

Purificación

Protein A/G purified from cell culture supernatant.

Número de acceso

P81172

Forma

Liquid

Buffer de almacenamiento

0.01M PBS pH 7.4.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.

Información de uso del producto

Aplicación	Dilución
WB	1:500-1:2000

Estabilidad y almacenamiento

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Nombres alternativos

LY2787106

Fondo

Hepcidin (HAMP) is a ~9 kDa protein. Liver-produced hormone that constitutes the main circulating regulator of iron absorption and distribution across tissues. Acts by promoting endocytosis and degradation of ferroportin/SLC40A1, leading to the retention of iron in iron-exporting cells and decreased flow of iron into plasma. Controls the major flows of iron into plasma: absorption of dietary iron in the intestine, recycling of iron by macrophages, which phagocytose old erythrocytes and other cells, and mobilization of stored iron from hepatocytes.

1. Qiao, B. et al. (2012) Cell metabolism 15, 918-24. PMID: 22682227

2. Aschemeyer, S. et al. (2018) Blood 131, 899-910. PMID: 29237594

3. Billesbølle, CB. et al. (2020) Nature 586, 807-811. PMID: 32814342

4. Ganz, T. et al. (2012) Biochimica et biophysica acta 1823, 1434-43. PMID: 22306005

Nota

For research use only. Not suitable for clinical or therapeutic use.

Isotype Control

Human IgG4 (S228P) Recombinant Isotype Control Antibody (13R4) (HP298207)

Imágenes

SDS-PAGE

SDS-PAGE for Research Grade Anti-Human HAMP/Hepcidin (LY2787106)
Bioactivity

Detects recombinant Hepcidin (Catalog No: HX911022) in indirect ELISA.
Western blot

Western blot analysis was performed using anti-Hepcidin monoclonal antibody at 1ug/mL on various samples.
Lane 1: recombinant human Hepcidin (Catalog No: HX911022)
Lane 2: Negative control