Anti-Human Hepcidin Reference Antibody (LY2787106, RUO) (HX911016)

Name: Anti-Human Hepcidin Reference Antibody (LY2787106, RUO)
Brand: abinScience
SKU: HX911016
Price: 370 USD
Availability: InStock

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100ug
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Reférences
Fiche technique
SDS

Aperçu

Numéro de catalogue

HX911016

Description

Anti-Human HAMP/Hepcidin (LY2787106) (HX911016) is a research-grade recombinant antibody targeting Putative liver tumor regressor. Produced in mammalian cells with native-like glycosylation.

Highlights

●Research Grade — For PK/PD studies, assay development, and ADA research.
●Native Glycosylation — Mammalian expression ensures native-like patterns.

Reactivité des espèces

Human

Applications

ELISA, Bioactivity: FCM, Functional assay, Research in vivo, WB

Espèce hôte

Human

Clonalité

Monoclonal

Isotype

IgG

ID de clone

LY2787106

Système d'expression

Mammalian cells

Applications testées

Cible

Putative liver tumor regressor, HEPC, LEAP-1, Liver-expressed antimicrobial peptide 1, PLTR, Hepcidin, LEAP1, Hepc25, Hepc20, HAMP

Niveau d'endotoxines

< 10 EU/mg

Pureté

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Numéro d'accès

P81172

Forme

Liquid

Tampon de stockage

0.01M PBS pH 7.4.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
WB	1:500-1:2000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Noms alternatifs

LY2787106

Contexte

Hepcidin (HAMP) is a ~9 kDa protein. Liver-produced hormone that constitutes the main circulating regulator of iron absorption and distribution across tissues. Acts by promoting endocytosis and degradation of ferroportin/SLC40A1, leading to the retention of iron in iron-exporting cells and decreased flow of iron into plasma. Controls the major flows of iron into plasma: absorption of dietary iron in the intestine, recycling of iron by macrophages, which phagocytose old erythrocytes and other cells, and mobilization of stored iron from hepatocytes.

1. Qiao, B. et al. (2012) Cell metabolism 15, 918-24. PMID: 22682227

2. Aschemeyer, S. et al. (2018) Blood 131, 899-910. PMID: 29237594

3. Billesbølle, CB. et al. (2020) Nature 586, 807-811. PMID: 32814342

4. Ganz, T. et al. (2012) Biochimica et biophysica acta 1823, 1434-43. PMID: 22306005

Note

For research use only. Not suitable for clinical or therapeutic use.

Isotype Control

Human IgG4 (S228P) Recombinant Isotype Control Antibody (13R4) (HP298207)

Images

SDS-PAGE

SDS-PAGE for Research Grade Anti-Human HAMP/Hepcidin (LY2787106)
Bioactivity

Detects recombinant Hepcidin (Catalog No: HX911022) in indirect ELISA.
Western blot

Western blot analysis was performed using anti-Hepcidin monoclonal antibody at 1ug/mL on various samples.
Lane 1: recombinant human Hepcidin (Catalog No: HX911022)
Lane 2: Negative control