Anti-Human Hepcidin Reference Antibody (LY2787106, RUO) (HX911016)

Name: Anti-Human Hepcidin Reference Antibody (LY2787106, RUO)
Brand: abinScience
SKU: HX911016
Price: 370 USD
Availability: InStock

データシート製品共有情報コピー

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100ug
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概要
イメージ
参考文献
データシート
SDS

概要

カタログ番号

HX911016

説明

Anti-Human HAMP/Hepcidin (LY2787106) (HX911016) is a research-grade recombinant antibody targeting Putative liver tumor regressor. Produced in mammalian cells with native-like glycosylation.

Highlights

●Research Grade — For PK/PD studies, assay development, and ADA research.
●Native Glycosylation — Mammalian expression ensures native-like patterns.

種反応性

Human

アプリケーション

ELISA, Bioactivity: FCM, Functional assay, Research in vivo, WB

宿主種

Human

クローン性

Monoclonal

アイソタイプ

IgG

クローンID

LY2787106

発現システム

Mammalian cells

テスト済みアプリケーション

ターゲット

Putative liver tumor regressor, HEPC, LEAP-1, Liver-expressed antimicrobial peptide 1, PLTR, Hepcidin, LEAP1, Hepc25, Hepc20, HAMP

エンドトキシンレベル

< 10 EU/mg

純度

>95% as determined by SDS-PAGE.

精製

Protein A/G purified from cell culture supernatant.

アクセッション番号

P81172

形態

Liquid

保存バッファー

0.01M PBS pH 7.4.

データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。

製品使用情報

アプリケーション	希釈
WB	1:500-1:2000

安定性と保存

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

別名

LY2787106

背景

Hepcidin (HAMP) is a ~9 kDa protein. Liver-produced hormone that constitutes the main circulating regulator of iron absorption and distribution across tissues. Acts by promoting endocytosis and degradation of ferroportin/SLC40A1, leading to the retention of iron in iron-exporting cells and decreased flow of iron into plasma. Controls the major flows of iron into plasma: absorption of dietary iron in the intestine, recycling of iron by macrophages, which phagocytose old erythrocytes and other cells, and mobilization of stored iron from hepatocytes.

1. Qiao, B. et al. (2012) Cell metabolism 15, 918-24. PMID: 22682227

2. Aschemeyer, S. et al. (2018) Blood 131, 899-910. PMID: 29237594

3. Billesbølle, CB. et al. (2020) Nature 586, 807-811. PMID: 32814342

4. Ganz, T. et al. (2012) Biochimica et biophysica acta 1823, 1434-43. PMID: 22306005

注意事項

For research use only. Not suitable for clinical or therapeutic use.

Isotype Control

Human IgG4 (S228P) Recombinant Isotype Control Antibody (13R4) (HP298207)

イメージ

SDS-PAGE

SDS-PAGE for Research Grade Anti-Human HAMP/Hepcidin (LY2787106)
Bioactivity

Detects recombinant Hepcidin (Catalog No: HX911022) in indirect ELISA.
Western blot

Western blot analysis was performed using anti-Hepcidin monoclonal antibody at 1ug/mL on various samples.
Lane 1: recombinant human Hepcidin (Catalog No: HX911022)
Lane 2: Negative control