Anti-Human Hepcidin Reference Antibody (LY2787106, RUO) (HX911016)

Name: Anti-Human Hepcidin Reference Antibody (LY2787106, RUO)
Brand: abinScience
SKU: HX911016
Price: 370 USD
Availability: InStock

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Спецификация:

100ug
1mg
5mg
10mg
25mg
50mg
100mg

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Обзор
Изображения
Ссылки
Даташит
SDS

Обзор

Каталожный номер

HX911016

Описание

Anti-Human HAMP/Hepcidin (LY2787106) (HX911016) is a research-grade recombinant antibody targeting Putative liver tumor regressor. Produced in mammalian cells with native-like glycosylation.

Highlights

●Research Grade — For PK/PD studies, assay development, and ADA research.
●Native Glycosylation — Mammalian expression ensures native-like patterns.

Реактивность видов

Human

Применения

ELISA, Bioactivity: FCM, Functional assay, Research in vivo, WB

Хозяинский вид

Human

Клоональность

Monoclonal

Изотип

IgG

ID клона

LY2787106

Система экспрессии

Mammalian cells

Проверенные приложения

Цель

Putative liver tumor regressor, HEPC, LEAP-1, Liver-expressed antimicrobial peptide 1, PLTR, Hepcidin, LEAP1, Hepc25, Hepc20, HAMP

Уровень эндотоксинов

< 10 EU/mg

Чистота

>95% as determined by SDS-PAGE.

Очистка

Protein A/G purified from cell culture supernatant.

Номер доступа

P81172

Форма

Liquid

Буфер хранения

0.01M PBS pH 7.4.

Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.

Информация об использовании продукта

Применение	Разбавление
WB	1:500-1:2000

Устойчивость и хранение

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Альтернативные названия

LY2787106

Фон

Hepcidin (HAMP) is a ~9 kDa protein. Liver-produced hormone that constitutes the main circulating regulator of iron absorption and distribution across tissues. Acts by promoting endocytosis and degradation of ferroportin/SLC40A1, leading to the retention of iron in iron-exporting cells and decreased flow of iron into plasma. Controls the major flows of iron into plasma: absorption of dietary iron in the intestine, recycling of iron by macrophages, which phagocytose old erythrocytes and other cells, and mobilization of stored iron from hepatocytes.

1. Qiao, B. et al. (2012) Cell metabolism 15, 918-24. PMID: 22682227

2. Aschemeyer, S. et al. (2018) Blood 131, 899-910. PMID: 29237594

3. Billesbølle, CB. et al. (2020) Nature 586, 807-811. PMID: 32814342

4. Ganz, T. et al. (2012) Biochimica et biophysica acta 1823, 1434-43. PMID: 22306005

Примечание

For research use only. Not suitable for clinical or therapeutic use.

Isotype Control

Human IgG4 (S228P) Recombinant Isotype Control Antibody (13R4) (HP298207)

Изображения

SDS-PAGE

SDS-PAGE for Research Grade Anti-Human HAMP/Hepcidin (LY2787106)
Bioactivity

Detects recombinant Hepcidin (Catalog No: HX911022) in indirect ELISA.
Western blot

Western blot analysis was performed using anti-Hepcidin monoclonal antibody at 1ug/mL on various samples.
Lane 1: recombinant human Hepcidin (Catalog No: HX911022)
Lane 2: Negative control