Anti-Human IL-11 Reference Antibody (BI 765423, RUO) (HB978026)

Name: Anti-Human IL-11 Reference Antibody (BI 765423, RUO)
Brand: abinScience
SKU: HB978026
Price: 176 USD
Availability: InStock

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Каталожный номер	HB978026
Реактивность видов	Human
Применения	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Хозяинский вид	Human
Изотип	IgG
ID клона	BI 765423
Биологическая активность	In in vitro experiments using human fibroblasts, BI-765423 significantly inhibits fibroblast activation and reduced the progression of inflammation- and senescence-related pathological processes [1] [2]. In in vitro cellular senescence transformation experiments using human cells, BI-765423 effectively counteractes cellular senescence transformation, demonstrating potential anti-aging activity [1]. BI-765423 can extend the healthy lifespan of mammals by inhibiting IL-11 signaling, and also has inhibitory effects on pathological processes associated with idiopathic pulmonary fibrosis (IPF) [1] [2].
Система экспрессии	Mammalian cells
Цель	Adipogenesis inhibitory factor, AGIF, IL11, IL-11, Interleukin-11, Oprelvekin
Уровень эндотоксинов	< 10 EU/mg
Чистота	>95% purity as determined by SDS-PAGE.
Очистка	Protein A/G purified from cell culture supernatant.
Номер доступа	P20809
Форма	Liquid
Буфер хранения	0.01M PBS pH 7.4 Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.
Устойчивость и хранение	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Альтернативные названия	BI-765423, BI765423, BI765423
Фон	Interleukin-11 (IL11) is a ~21 kDa protein. Cytokine that stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production. Also promotes the proliferation of hepatocytes in response to liver damage. Binding to its receptor formed by IL6ST and IL11RA activates a signaling cascade that promotes cell proliferation. Signaling leads to the activation of intracellular protein kinases and the phosphorylation of STAT3. The interaction with the membrane-bound IL11RA and IL6ST stimulates 'classic signaling', whereas the binding of IL11 and soluble IL11RA to IL6ST stimulates 'trans-signaling'. 1. Paul, SR. et al. (1990) Proceedings of the National Academy of Sciences of the United States of America 87, 7512-6. PMID: 2145578 2. Harmegnies, D. et al. (2003) The Biochemical journal 375, 23-32. PMID: 12919066 3. Lamertz, L. et al. (2018) Science signaling 11. PMID: 30279168
Ссылки	1. Pudewell S, et al. Targeting the major pro-inflammatory interleukin-6-type cytokine receptor gp130 by antagonistic single domain antibodies. Front Immunol. 2025 Aug 15;16:1613004. [HB978026] 2. Zhavoronkov A, et al. Age-related diseases as a testbed for anti-aging therapeutics: the case of idiopathic pulmonary fibrosis. Aging (Albany NY). 2025 Aug 16;17(8):1911-1928. [HB978026]
Примечание	For research use only. Not suitable for clinical or therapeutic use.
Isotype Control	Human IgG1 (LALA) Recombinant Isotype Control Antibody (HyHEL-10) (HP688107) Human IgG1 (LALAPG) Recombinant Isotype Control Antibody (HyHEL-10) (HP688307)