Anti-Human IL-11 Reference Antibody (X203, RUO) (HB978016)

Name: Anti-Human IL-11 Reference Antibody (X203, RUO)
Brand: abinScience
SKU: HB978016
Price: 176 USD
Availability: InStock

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100ug
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Vista general

Número de catálogo	HB978016
Descripción	Anti-Human IL11 Antibody (X203) (HB978016) is a research-grade recombinant antibody targeting Adipogenesis inhibitory factor. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Reactividad de especies	Human
Aplicaciones	ELISA, Functional assay, Research in vivo
Especie huésped	Human
Clonalidad	Monoclonal
Isotipo	IgG1, kappa
ID de clon	X203
Sistema de expresión	Mammalian cells
Aplicaciones probadas	WB
Objetivo	Adipogenesis inhibitory factor, AGIF, IL11, IL-11, Interleukin-11, Oprelvekin
Nivel de endotoxinas	< 10 EU/mg
Pureza	>95% purity as determined by SDS-PAGE.
Purificación	Protein A/G purified from cell culture supernatant.
Número de acceso	P20809
Forma	Liquid
Buffer de almacenamiento	0.01M PBS pH 7.4 Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Estabilidad y almacenamiento	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Nombres alternativos	EnX203, EnX203, EnX-203, X203
Fondo	Interleukin-11 (IL11) is a ~21 kDa protein. Cytokine that stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production. Also promotes the proliferation of hepatocytes in response to liver damage. Binding to its receptor formed by IL6ST and IL11RA activates a signaling cascade that promotes cell proliferation. Signaling leads to the activation of intracellular protein kinases and the phosphorylation of STAT3. The interaction with the membrane-bound IL11RA and IL6ST stimulates 'classic signaling', whereas the binding of IL11 and soluble IL11RA to IL6ST stimulates 'trans-signaling'. 1. Paul, SR. et al. (1990) Proceedings of the National Academy of Sciences of the United States of America 87, 7512-6. PMID: 2145578 2. Harmegnies, D. et al. (2003) The Biochemical journal 375, 23-32. PMID: 12919066 3. Lamertz, L. et al. (2018) Science signaling 11. PMID: 30279168
Nota	For research use only. Not suitable for clinical or therapeutic use.
Isotype Control	Human IgG1 (LALA) Recombinant Isotype Control Antibody (HyHEL-10) (HP688107) Human IgG1 (LALAPG) Recombinant Isotype Control Antibody (HyHEL-10) (HP688307)

Imágenes

SDS-PAGE

SDS-PAGE for Research Grade Anti-Human IL11 Antibody (X203).
Bioactivity

Detects Human IL11 in indirect ELISAs.
Bioactivity

Detects Recombinant Human IL11 Protein, N-His (Catalog No: HB978012) in indirect ELISAs.
Bioactivity

Detects Recombinant Human IL11 Protein, N-His (Catalog No: HB978022) in indirect ELISAs.
Bioactivity

Detects Recombinant Human IL11 Protein, N-His (Catalog No: HB978032) in indirect ELISAs.
Western blot

Western blot analysis was performed using anti-IL11 monoclonal antibody at 1μg/ml on various samples.
Lane 1: recombinant human IL11 (Catalog No: HB978012), 50ng
Lane 2: recombinant human IL11 (Catalog No: HB978012), 30ng
Western blot

Western blot analysis was performed using anti-/ monoclonal antibody at 1ug/mL on various samples.
Lane 1: recombinant feline IL-11