Anti-Human IL-11 Reference Antibody (X203, RUO) (HB978016)

Name: Anti-Human IL-11 Reference Antibody (X203, RUO)
Brand: abinScience
SKU: HB978016
Price: 176 USD
Availability: InStock

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100ug
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概要
イメージ
参考文献
データシート
SDS

概要

カタログ番号	HB978016
説明	Anti-Human IL11 Antibody (X203) (HB978016) is a research-grade recombinant antibody targeting Adipogenesis inhibitory factor. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
種反応性	Human
アプリケーション	ELISA, Functional assay, Research in vivo
宿主種	Human
クローン性	Monoclonal
アイソタイプ	IgG1, kappa
クローンID	X203
発現システム	Mammalian cells
テスト済みアプリケーション	WB
ターゲット	Adipogenesis inhibitory factor, AGIF, IL11, IL-11, Interleukin-11, Oprelvekin
エンドトキシンレベル	< 10 EU/mg
純度	>95% purity as determined by SDS-PAGE.
精製	Protein A/G purified from cell culture supernatant.
アクセッション番号	P20809
形態	Liquid
保存バッファー	0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。
安定性と保存	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
別名	EnX203, EnX203, EnX-203, X203
背景	Interleukin-11 (IL11) is a ~21 kDa protein. Cytokine that stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production. Also promotes the proliferation of hepatocytes in response to liver damage. Binding to its receptor formed by IL6ST and IL11RA activates a signaling cascade that promotes cell proliferation. Signaling leads to the activation of intracellular protein kinases and the phosphorylation of STAT3. The interaction with the membrane-bound IL11RA and IL6ST stimulates 'classic signaling', whereas the binding of IL11 and soluble IL11RA to IL6ST stimulates 'trans-signaling'. 1. Paul, SR. et al. (1990) Proceedings of the National Academy of Sciences of the United States of America 87, 7512-6. PMID: 2145578 2. Harmegnies, D. et al. (2003) The Biochemical journal 375, 23-32. PMID: 12919066 3. Lamertz, L. et al. (2018) Science signaling 11. PMID: 30279168
注意事項	For research use only. Not suitable for clinical or therapeutic use.
Isotype Control	Human IgG1 (LALA) Recombinant Isotype Control Antibody (HyHEL-10) (HP688107) Human IgG1 (LALAPG) Recombinant Isotype Control Antibody (HyHEL-10) (HP688307)

イメージ

SDS-PAGE

SDS-PAGE for Research Grade Anti-Human IL11 Antibody (X203).
Bioactivity

Detects Human IL11 in indirect ELISAs.
Bioactivity

Detects Recombinant Human IL11 Protein, N-His (Catalog No: HB978012) in indirect ELISAs.
Bioactivity

Detects Recombinant Human IL11 Protein, N-His (Catalog No: HB978022) in indirect ELISAs.
Bioactivity

Detects Recombinant Human IL11 Protein, N-His (Catalog No: HB978032) in indirect ELISAs.
Western blot

Western blot analysis was performed using anti-IL11 monoclonal antibody at 1μg/ml on various samples.
Lane 1: recombinant human IL11 (Catalog No: HB978012), 50ng
Lane 2: recombinant human IL11 (Catalog No: HB978012), 30ng
Western blot

Western blot analysis was performed using anti-/ monoclonal antibody at 1ug/mL on various samples.
Lane 1: recombinant feline IL-11