Anti-Human IL-1Rrp2/IL-1R6 Reference Antibody (REGN6490, RUO) (HV045016)

Name: Anti-Human IL-1Rrp2/IL-1R6 Reference Antibody (REGN6490, RUO)
Brand: abinScience
SKU: HV045016
Price: 370 USD
Availability: InStock

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Numéro de catalogue	HV045016
Description	Anti-Human IL-1Rrp2/IL-1R6 Reference Antibody (REGN6490, RUO) (HV045016) is a human monoclonal antibody detecting IL-1Rrp2/IL-1R6. Expressed in Mammalian cells.
Reactivité des espèces	Human
Applications	ELISA, Bioactivity: FCM, Functional assay, Research in vivo
Espèce hôte	Human
Clonalité	Monoclonal
Isotype	IgG4, kappa
ID de clone	REGN6490
Système d'expression	Mammalian cells
Nature	Recombinant
Cible	IL1R-rp2, IL1RL2, IL1RRP2, IL-1Rrp2, IL-36 receptor, Interleukin-1 receptor-related protein 2, Interleukin-1 receptor-like 2, IL-36R
Niveau d'endotoxines	< 10 EU/mg as determined by LAL method.
Pureté	>95% as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Numéro d'accès	Q9HB29
Forme	Liquid
Tampon de stockage	0.01M PBS pH 7.4. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Stabilité et stockage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Noms alternatifs	REGN6490
Contexte	Interleukin-1 receptor-like 2 (IL1RL2/IL-36R) is a ~65 kDa protein. Receptor for interleukin-36 (IL36A, IL36B and IL36G). After binding to interleukin-36 associates with the coreceptor IL1RAP to form the interleukin-36 receptor complex which mediates interleukin-36-dependent activation of NF-kappa-B, MAPK and other pathways. The IL-36 signaling system is thought to be present in epithelial barriers and to take part in local inflammatory response; it is similar to the IL-1 system. Seems to be involved in skin inflammatory response by induction of the IL-23/IL-17/IL-22 pathway.
Reférences	1. Jason E Hawkes, et al. The role of the interleukin-36 axis in generalized pustular psoriasis: a review of the mechanism of action of spesolimab. Front Immunol. 2023 Nov 21:14:1292941. [HV045016]
Note	For research use only. Not suitable for clinical or therapeutic use.

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SDS-PAGE for Research Grade Anti-Human IL1RL2/IL-36R (REGN6490)

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Anti-Human IL-1Rrp2/IL-1R6 Reference Antibody (REGN6490, RUO).pdf

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Anti-Human IL-1Rrp2/IL-1R6 Reference Antibody (REGN6490, RUO) (HV045016)

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