Anti-Human Galectin-9 Reference Antibody (HFB200901, RUO) (HT173036)

Name: Anti-Human Galectin-9 Reference Antibody (HFB200901, RUO)
Brand: abinScience
SKU: HT173036
Price: 370 USD
Availability: InStock

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100ug
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概要
イメージ
参考文献
データシート
SDS

概要

カタログ番号	HT173036
種反応性	Human
アプリケーション	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
宿主種	Human
クローン性	Monoclonal
アイソタイプ	IgG
クローンID	HFB200901
生物学的活性	Anti-LGALS9 (HFB200901) (10 ug/mL; 1 h) potently inhibits rLGALS9-induced vacuolization in MDCK and DLD-1 KRAS G12C mutant colon carcinoma cells [1]. HFB200901 (20 ug-10 mg; s.c.; once weekly; 8 weeks) reduces pancreatic LGALS9 expression, lowers peripheral and infiltrating Treg levels, increases pancreatic-infiltrating CD4 + T cells, and limits PanIN progression in KC mice [2].
発現システム	Mammalian cells
ターゲット	Ecalectin, LGALS9, Galectin-9, Gal-9, Tumor antigen HOM-HD-21
エンドトキシンレベル	< 10 EU/mg
純度	>95% purity as determined by SDS-PAGE.
精製	Protein A/G purified from cell culture supernatant.
アクセッション番号	O00182
形態	Liquid
保存バッファー	0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。
安定性と保存	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
別名	HFB200901
背景	Galectin-9 (Gal-9) is a ~39 kDa protein. Binds galactosides. Has high affinity for the Forssman pentasaccharide. Ligand for HAVCR2/TIM3. Binding to HAVCR2 induces T-helper type 1 lymphocyte (Th1) death. Also stimulates bactericidal activity in infected macrophages by causing macrophage activation and IL1B secretion which restricts intracellular bacterial growth. 1. Nagae, M. et al. (2008) Journal of molecular biology 375, 119-35. PMID: 18005988 2. Zhu, C. et al. (2005) Nature immunology 6, 1245-52. PMID: 16286920 3. Bi, S. et al. (2011) Proceedings of the National Academy of Sciences of the United States of America 108, 10650-5. PMID: 21670307 4. Gieseke, F. et al. (2013) European journal of immunology 43, 2741-9. PMID: 23817958 5. Mengshol, JA. et al. (2010) PloS one 5, e9504. PMID: 20209097 6. Dai, SY. et al. (2005) Journal of immunology (Baltimore, Md. : 1950) 175, 2974-81. PMID: 16116184 7. Kojima, R. et al. (2014) PloS one 9, e86106. PMID: 24465902 9. Golden-Mason, L. et al. (2013) Journal of virology 87, 4835-45. PMID: 23408620
参考文献	1. Wiersma VR, et al. The epithelial polarity regulator LGALS9/galectin-9 induces fatal frustrated autophagy in KRAS mutant colon carcinoma that depends on elevated basal autophagic flux. Autophagy. 2015;11(8):1373-1388. [HT173036] 2. Quilbe A, et al. A novel anti-galectin-9 immunotherapy limits the early progression of pancreatic neoplastic lesions in transgenic mice. Front Immunol. 2023;14:1267279. Published 2023 Nov 30. [HT173036] 3. Pranjol M Z I, Zinovkin D A, Potapnev M P. The role of galectins in the immune microenvironment in human cancers and potential therapeutic approaches[J]. Frontiers in Immunology, 2024, 15: 1448407. [HT173036] 4. Lu B, et al. LGALS9 blockade augments vaccine-induced immune responses against prostate cancer. J Immunother Cancer. 2026;14(5):e014141. Published 2026 May 8. View More [HT173036]
注意事項	For research use only. Not suitable for clinical or therapeutic use.