Anti-Human MMP-14/MT1-MMP Reference Antibody (RLVT 14-02, RUO) (HW299036)

Name: Anti-Human MMP-14/MT1-MMP Reference Antibody (RLVT 14-02, RUO)
Brand: abinScience
SKU: HW299036
Price: 370 USD
Availability: InStock

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Обзор

Каталожный номер	HW299036
Описание	Anti-Human MMP14 Antibody (RLVT 14-02) (HW299036) is a research-grade recombinant antibody targeting MT-MMP 1. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Реактивность видов	Human
Применения	ELISA, Bioactivity: FCM, Functional assay, Research in vivo
Хозяинский вид	Human
Клоональность	Monoclonal
Изотип	IgG
ID клона	RLVT 14-02
Система экспрессии	Mammalian cells
Цель	MT-MMP 1, Matrix metalloproteinase-14, Membrane-type matrix metalloproteinase 1, Membrane-type-1 matrix metalloproteinase, MMP14, MTMMP1, MT1-MMP, MMP-14, MMP-X1, MT1MMP
Уровень эндотоксинов	< 10 EU/mg
Чистота	>95% as determined by SDS-PAGE.
Очистка	Protein A/G purified from cell culture supernatant.
Номер доступа	P50281
Форма	Liquid
Буфер хранения	0.01M PBS pH 7.4. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.
Устойчивость и хранение	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Альтернативные названия	RLVT14-02, RLVT-14-02, RLVT14-02
Фон	Matrix metalloproteinase-14 (MMP14) is a ~65 kDa protein. Endopeptidase that degrades various components of the extracellular matrix such as collagen. Essential for pericellular collagenolysis and modeling of skeletal and extraskeletal connective tissues during development. Activates progelatinase A/MMP2, thereby acting as a positive regulator of cell growth and migration. Involved in the formation of the fibrovascular tissues in association with pro-MMP2. May be involved in actin cytoskeleton reorganization by cleaving PTK7. 1. Sato, H. et al. (1994) Nature 370, 61-5. PMID: 8015608 2. Gu, G. et al. (2012) Journal of cellular biochemistry 113, 1013-21. PMID: 22065321 3. Noda, K. et al. (2003) Investigative ophthalmology & visual science 44, 2163-70. PMID: 12714657 4. Golubkov, VS. et al. (2010) The Journal of biological chemistry 285, 35740-9. PMID: 20837484 5. Jin, G. et al. (2011) The EMBO journal 30, 2281-93. PMID: 21572390 6. Cork, SM. et al. (2012) Oncogene 31, 5144-52. PMID: 22330140 7. Chow, CFW. et al. (2022) Nature metabolism 4, 203-212. PMID: 35177851
Примечание	For research use only. Not suitable for clinical or therapeutic use.
Isotype Control	Human IgG1 Recombinant Isotype Control Antibody (13R4) (HV080507)

Изображения

SDS-PAGE

SDS-PAGE for Research Grade Anti-Human MMP14 Antibody (RLVT 14-02)
Immunofluorescence

Immunofluorescence staining of HepG2 with Human monoclonal antibody (20ug/ml, overnight at 4°C), followed by Alexa Fluor-488-conjugated secondary antibody (6.5ug/ml, 50minutes at room temperature). The target protein was detected in the cell membrane.