Anti-Human beta-NGF Reference Antibody (MEDI1912, RUO) (HF909066)

Name: Anti-Human beta-NGF Reference Antibody (MEDI1912, RUO)
Brand: abinScience
SKU: HF909066
Price: 370 USD
Availability: InStock

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Número de catálogo	HF909066
Descripción	Anti-Human NGF/Beta-NGF (MEDI1912) (HF909066) is a research-grade recombinant antibody targeting Beta-nerve growth factor. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Reactividad de especies	Human
Aplicaciones	ELISA, Bioactivity: FCM, Functional assay, Research in vivo
Especie huésped	Human
Clonalidad	Monoclonal
Isotipo	IgG
ID de clon	MEDI1912
Objetivo	Beta-NGF, Beta-nerve growth factor, NGF, NGFB
Nivel de endotoxinas	< 10 EU/mg
Pureza	>95% as determined by SDS-PAGE.
Purificación	Protein A/G purified from cell culture supernatant.
Número de acceso	P01138
Forma	Liquid
Buffer de almacenamiento	0.01M PBS pH 7.4. Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Estabilidad y almacenamiento	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Nombres alternativos	MEDI1912
Fondo	Beta-nerve growth factor (NGF/Beta-NGF) is a ~26 kDa protein. Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades to regulate neuronal proliferation, differentiation and survival (Probable). The immature NGF precursor (proNGF) functions as a ligand for the heterodimeric receptor formed by SORCS2 and NGFR, and activates cellular signaling cascades that lead to inactivation of RAC1 and/or RAC2, reorganization of the actin cytoskeleton and neuronal growth cone collapse. In contrast to mature NGF, the precursor form (proNGF) promotes neuronal apoptosis (in vitro). Inhibits metalloproteinase-dependent proteolysis of platelet glycoprotein VI. 1. Einarsdottir, E. et al. (2004) Human molecular genetics 13, 799-805. PMID: 14976160 2. Carvalho, OP. et al. (2011) Journal of medical genetics 48, 131-5. PMID: 20978020 3. Wijeyewickrema, LC. et al. (2010) The Journal of biological chemistry 285, 11793-9. PMID: 20164177
Nota	For research use only. Not suitable for clinical or therapeutic use.