Anti-Human beta-NGF Reference Antibody (Relfovetmab, RUO) (FF909026)

Name: Anti-Human beta-NGF Reference Antibody (Relfovetmab, RUO)
Brand: abinScience
SKU: FF909026
Price: 176 USD
Availability: InStock

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Overview

Catalog No.	FF909026
Description	Research Grade Relfovetmab (FF909026) is a felinized monoclonal antibody detecting Nerve Growth Factor beta subunit in ELISA, Bioactivity: FACS, Functional assay, Research in vivo. Suitable for Cat. Highlights ●Multi-Application — Validated across multiple applications.
Species reactivity	Feline
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Host species	Feline
Isotype	IgG1-kappa
Expression system	Mammalian cells
Species	Cat
Clonality	Monoclonal
Target	Nerve Growth Factor beta subunit, ngfb
Endotoxin level	Please contact with the lab for this information.
Purity	>95% as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	Q6ZY27
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	ZTS-00084768, 2171034-70-9
Background	Frunevetmab (NV-02) is a felinized anti-nerve growth factor (NGF) monoclonal antibody with a Kd of 20 pM. Frunevetmab can effectively decrease osteoarthritis (OA) pain in cats. • Nerve growth factor β polypeptide (NGFB) genetic variability: association with the methadone dose required for effective maintenance treatment., PMID:21358750 • Synthesis of the biologically active beta-subunit of human nerve growth factor in Escherichia coli., PMID:1537563 • Nerve growth factor translates stress response and subsequent murine abortion via adhesion molecule-dependent pathways., PMID:16371592 • Two thyroid hormone regulated genes, the beta-subunits of nerve growth factor (NGFB) and thyroid stimulating hormone (TSHB), are located less than 310 kb apart in both human and mouse genomes., PMID:2906326 • Nerve growth factor and the physiology of pain: lessons from congenital insensitivity to pain with anhidrosis., PMID:22882139 • A mutation in the nerve growth factor beta gene (NGFB) causes loss of pain perception., PMID:14976160 • Rare human nerve growth factor-β mutation reveals relationship between C-afferent density and acute pain evaluation., PMID:27146986 • Linkage relationships of the gene for the beta subunit of nerve growth factor (NGFB) with other chromosome 1 marker loci., PMID:4006521 • Nerve growth factor exhibits an antioxidant and an autocrine activity in mouse liver that is modulated by buthionine sulfoximine, arsenic, and acetaminophen., PMID:23472850 • Assignment of the beta-nerve growth factor (NGFB) to bovine chromosome 3 band q23 by in situ hybridization., PMID:9284944
Note	For research use only. Not suitable for clinical or therapeutic use.