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| カタログ番号 | HS752016 |
|---|---|
| 説明 |
Anti-Human NONO (PAT-LM1) (HS752016) is a research-grade recombinant antibody targeting 54 kDa nuclear RNA- and DNA-binding protein. Produced in mammalian cells with native-like glycosylation.
Highlights
|
| 種反応性 | Human |
| アプリケーション | ELISA, Bioactivity: FACS, Functional assay, Research in vivo |
| 宿主種 | Human |
| クローン性 | Monoclonal |
| アイソタイプ | IgG |
| クローンID | PAT-LM1 |
| 発現システム | Mammalian cells |
| ターゲット | 54 kDa nuclear RNA- and DNA-binding protein, NRB54, p54nrb, NMT55, NonO protein, p54(nrb), 55 kDa nuclear protein, NONO, DNA-binding p52/p100 complex, 52 kDa subunit, Non-POU domain-containing octamer-binding protein |
| エンドトキシンレベル | < 10 EU/mg |
| 純度 | >95% purity as determined by SDS-PAGE. |
| 精製 | Protein A/G purified from cell culture supernatant. |
| アクセッション番号 | Q15233 |
| 形態 | Liquid |
| 保存バッファー | 0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 別名 | PAT-LM1, PATLM1, PATLM1 |
| 背景 | Non-POU domain-containing octamer-binding protein (NONO) is a ~54 kDa protein. DNA- and RNA binding protein, involved in several nuclear processes. Binds the conventional octamer sequence in double-stranded DNA. Also binds single-stranded DNA and RNA at a site independent of the duplex site. Involved in pre-mRNA splicing, probably as a heterodimer with SFPQ. Interacts with U5 snRNA, probably by binding to a purine-rich sequence located on the 3' side of U5 snRNA stem 1b. 1. Zhang, Z. et al. (2001) Cell 106, 465-75. PMID: 11525732 2. Peng, R. et al. (2002) RNA (New York, N.Y.) 8, 1334-47. PMID: 12403470 3. Mircsof, D. et al. (2015) Nature neuroscience 18, 1731-6. PMID: 26571461 8. Morchikh, M. et al. (2017) Molecular cell 67, 387-399.e5. PMID: 28712728 |
| 注意事項 | For research use only. Not suitable for clinical or therapeutic use. |
SDS-PAGE for Research Grade Anti-Human NONO (PAT-LM1)
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