Anti-Human TrkA Reference Antibody (GBR 900, RUO) (HY107016)

Name: Anti-Human TrkA Reference Antibody (GBR 900, RUO)
Brand: abinScience
SKU: HY107016
Price: 326 USD
Availability: InStock

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Numéro de catalogue	HY107016
Description	Anti-Human NTRK1/TRKA (GBR 900) (HY107016) is a research-grade recombinant antibody targeting Trk-A. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Reactivité des espèces	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Espèce hôte	Human
Clonalité	Monoclonal
Isotype	IgG
ID de clone	GBR 900
Système d'expression	Mammalian cells
Cible	Trk-A, High affinity nerve growth factor receptor, NTRK1, Tropomyosin-related kinase A, Neurotrophic tyrosine kinase receptor type 1, MTC, TRKA, Tyrosine kinase receptor, TRK, p140-TrkA, TRK1-transforming tyrosine kinase protein, gp140trk, Tyrosine kinase receptor A
Niveau d'endotoxines	< 10 EU/mg
Pureté	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Numéro d'accès	P04629
Forme	Liquid
Tampon de stockage	0.01M PBS pH 7.4 Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Stabilité et stockage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Noms alternatifs	GBR-900, GBR900, GBR900
Contexte	High affinity nerve growth factor receptor (NTRK1/TRKA) is a ~87 kDa protein. Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and nervous neurons. High affinity receptor for NGF which is its primary ligand. Can also bind and be activated by NTF3/neurotrophin-3. However, NTF3 only supports axonal extension through NTRK1 but has no effect on neuron survival. Upon dimeric NGF ligand-binding, undergoes homodimerization, autophosphorylation and activation. 1. Jing, S. et al. (1992) Neuron 9, 1067-79. PMID: 1281417 2. Tacconelli, A. et al. (2004) Cancer cell 6, 347-60. PMID: 15488758 3. Wehrman, T. et al. (2007) Neuron 53, 25-38. PMID: 17196528 4. Klein, R. et al. (1991) Cell 65, 189-97. PMID: 1849459 5. Hempstead, BL. et al. (1991) Nature 350, 678-83. PMID: 1850821 6. Tong, Q. et al. (2012) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 26, 3811-21. PMID: 22649032 7. Anta, B. et al. (2016) The Journal of biological chemistry 291, 19132-45. PMID: 27445338 8. Barker, PA. et al. (1993) The Journal of biological chemistry 268, 15150-7. PMID: 8325889
Note	For research use only. Not suitable for clinical or therapeutic use.