Anti-Human NTRK1 Monoclonal Antibody (1A717) (HY107015)

Name: Anti-Human NTRK1 Monoclonal Antibody (1A717)
Brand: abinScience
SKU: HY107015
Price: 106 USD
Availability: InStock

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Overview

Catalog No.	HY107015
Description	Anti-Human NTRK1 Monoclonal Antibody (1A717) [1A717] (HY107015) is a mouse monoclonal antibody detecting NTRK1 in ELISA, IHC, WB. Suitable for Human. Highlights ●Recombinant — Superior batch-to-batch reproducibility with defined sequences. ●Multi-Application — Validated across multiple applications.
Species reactivity	Human
Applications	ELISA, IHC, WB
Host species	Mouse
Isotype	IgG
Clone ID	1A717
Clonality	Monoclonal
Immunogen	E. coli - derived recombinant human NTRK1 (Asp38-Phe378).
Target	High affinity nerve growth factor receptor, EC:2.7.10.1, Neurotrophic tyrosine kinase receptor type 1, TRK1-transforming tyrosine kinase protein, Tropomyosin-related kinase A, Tyrosine kinase receptor, Tyrosine kinase receptor A, Trk-A, gp140trk, p140-TrkA, NTRK1
Purification	Protein A/G purified from cell culture supernatant.
Accession	P04629
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background	High affinity nerve growth factor receptor (NTRK1) is a ~87 kDa protein. Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and nervous neurons. High affinity receptor for NGF which is its primary ligand. Can also bind and be activated by NTF3/neurotrophin-3. However, NTF3 only supports axonal extension through NTRK1 but has no effect on neuron survival. Upon dimeric NGF ligand-binding, undergoes homodimerization, autophosphorylation and activation. 1. Jing, S. et al. (1992) Neuron 9, 1067-79. PMID: 1281417 2. Tacconelli, A. et al. (2004) Cancer cell 6, 347-60. PMID: 15488758 3. Wehrman, T. et al. (2007) Neuron 53, 25-38. PMID: 17196528 4. Klein, R. et al. (1991) Cell 65, 189-97. PMID: 1849459 5. Hempstead, BL. et al. (1991) Nature 350, 678-83. PMID: 1850821 6. Tong, Q. et al. (2012) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 26, 3811-21. PMID: 22649032 7. Anta, B. et al. (2016) The Journal of biological chemistry 291, 19132-45. PMID: 27445338 8. Barker, PA. et al. (1993) The Journal of biological chemistry 268, 15150-7. PMID: 8325889
Note	For research use only.